Evidence map›Paper›PMID 40943049›Full record

ArticleInternational journal of molecular sciences2025

NFATc1 Abrogation in B Cells Ameliorates Contact Hypersensitivity Responses.

Franziska Grän, Muhammad Azeem, Edgar Serfling, Matthias Goebeler, Andreas Kerstan, Khalid Muhammad

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Franziska GränDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.
Muhammad AzeemDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-4440-1039
Edgar SerflingDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, 97078 Würzburg, Germany.
Matthias GoebelerDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0001-7095-9848
Andreas KerstanDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0001-6483-0191
Khalid MuhammadDepartment of Biology, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates.ORCID 0000-0001-6488-1722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease that evolves upon exposure to contact allergens in sensitized individuals. Both the adaptive and innate immune system play pivotal roles in the pathogenesis of ACD. While the importance of T cells is undisputed, the relevance of B lymphocytes is less clear. The published data support a critical role for NFATc1 in B cell activation. Therefore, we investigated the impact of NFATc1 on B cell function during murine contact hypersensitivity (CHS), the mouse model for human ACD. Compared with wild-type mice, B cell-specific ablation of NFATc1 (

Indexed as

B-LymphocytesDermatitis, Allergic ContactDermatitis, ContactNFATC Transcription FactorsAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalInterleukin-10Lymphocyte ActivationMiceMice, Inbred C57BLInterleukin-10Nfatc1 protein, mouseNFATC Transcription FactorsB-lymphocytescontact hypersensitivityinterleukin-10NFATc1 transcription factorregulatory B-lymphocytes

Identifiers

PMID40943049
PMCPMC12428475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.