ArticleSensors (Basel, Switzerland)2025
Prediction of Germline BRCA Mutations in High-Risk Breast Cancer Patients Using Machine Learning with Multiparametric Breast MRI Features.
Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- AI-driven multi-omics integration in breast cancer: clinical applications, immunotherapy prediction, and translational challenges.Frontiers in molecular biosciences · 2026Review
- Prediction of germline BRCA mutation using clinicopathologic, MRI semantic, and radiomics features in high-risk breast cancer patients: a multicenter study.Frontiers in radiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The identification of germline BRCA1/2 (BRCA) mutations plays an important role in the treatment planning of high-risk breast cancer patients, but genetic testing may be costly or unavailable. The multiparametric breast MRI (mpMRI) features offer noninvasive imaging biomarkers that could support BRCA mutation prediction. In this study, we investigate whether mpMRI features can predict BRCA mutation status in high-risk breast cancer patients. We collected data from 231 consecutive patients (82 BRCA-positive, 149 BRCA-negative) who underwent BRCA mutation testing and preoperative MRI between 2013 and 2019. We used the mpMRI features, including computer-aided diagnosis (CAD)-derived kinetic features, morphologic features, and apparent diffusion coefficient (ADC) values from diffusion-weighted imaging (DWI). In the univariate analysis, higher CAD-derived washout component and peak enhancement, larger tumor size and angio-volume, peritumoral edema on T2-weighted imaging, axillary adenopathy, and minimal or mild background parenchymal enhancement (BPE) were significantly associated with BRCA mutation, while ADC values showed no significant differences. In the multivariate analysis, three significant predictors were washout component ≥ 19.5% (odds ratio [OR] = 3.89,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.