Evidence map›Paper›PMID 40942819›Full record

Observational studySensors (Basel, Switzerland)2025

Time-Domain Analysis of Low- and High-Frequency Near-Infrared Spectroscopy Sensor Technologies for Characterization of Cerebral Pressure-Flow and Oxygen Delivery Physiology: A Prospective Observational Study.

Amanjyot Singh Sainbhi, Nuray Vakitbilir, Tobias Bergmann, Kevin Y Stein, Rakibul Hasan, Noah Silvaggio, Mansoor Hayat, Jaewoong Moon, Frederick A Zeiler

Abstract readObservational Study
In one paragraph

Observational study in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amanjyot Singh SainbhiDepartment of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.ORCID 0000-0003-3231-5683
Nuray VakitbilirDepartment of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.ORCID 0000-0003-2764-145X
Tobias BergmannDepartment of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.ORCID 0009-0001-1082-6485
Kevin Y SteinDepartment of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.ORCID 0000-0002-5983-008X
Rakibul HasanDepartment of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.
Noah SilvaggioDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 0J9, Canada.ORCID 0009-0003-3860-8134
Mansoor HayatSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 1R9, Canada.ORCID 0000-0002-1131-2398
Jaewoong MoonSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 1R9, Canada.ORCID 0000-0002-8062-0570
Frederick A ZeilerDepartment of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.ORCID 0000-0003-1737-0510

Funding

Natural Sciences and Engineering Research Council ALLRP-578524-22Natural Sciences and Engineering Research Council RGPIN-2022-03621University of Manitoba Endowed Mani-501 toba Public Insurance (MPI) Chair in Neuroscience
6 · The paper itself

Abstract

Cerebrovascular reactivity, cerebral autoregulation (CA), and oxygen delivery can be measured continuously and in a non-invasive fashion using cerebral near-infrared spectroscopy (NIRS). Although the literature is limited surrounding the difference between signals acquired and derived from low (<100 Hz) and high sampling rates (≥100 Hz). As part of a prospective observational study, we preliminarily explored and assessed the difference in the information provided by two NIRS systems using regional cerebral oxygen saturation and cerebral oximetry index signals at low and high sampling rates. The raw data in two frequencies (down-sampled to 1 Hz using the mean and up-sampled to 250 Hz) were decimated to focus on slow-wave vasogenic fluctuations associated with CA. Then, the data were analyzed using various statistical methods such as the absolute signal difference, Pearson correlation, Bland-Altman agreement, Cross-correlation function, optimal time-series autocorrelative structure, time-series impulse response function, and Granger causality relationships. The results of the various statistical analyses indicated that the signals obtained using high-frequency NIRS were different from signals obtained from low-frequency NIRS of the same cerebral region. Hence, high-frequency NIRS systems may possibly contain better signal features compared to NIRS systems with low sampling rates, but further work is required to assess high-frequency NIRS in other healthy and cranial trauma populations.

Indexed as

BrainCerebrovascular CirculationOximetryOxygenAdultFemaleHumansMaleOxygen SaturationProspective StudiesSpectroscopy, Near-InfraredOxygenARIMA structurecerebral oximetry indexregional cerebral oxygen saturationtime domaintime series

Identifiers

PMID40942819
PMCPMC12430896

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.