Evidence map›Paper›PMID 40942340›Full record

ArticlePolymers2025

Methylcellulose-Encapsulated Magnesium-Substituted Biphasic Calcium Phosphate Granules for Local Drug Delivery in Bone Tissue Engineering: Modification for Prolonged Release and Antibacterial Behavior.

Daniil O Golubchikov, Inna V Fadeeva, Elena S Trofimchuk, Katia Barbaro, Viktoriya G Yankova, Iulian V Antoniac, Valery I Putlayev, Julietta V Rau, Vicentiu Saceleanu

Abstract read
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In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniil O GolubchikovChemistry Department, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.ORCID 0000-0001-8488-6387
Inna V FadeevaA.A. Baikov Institute of Metallurgy and Material Science, Russian Academy of Sciences, Leninsky 49, 119334 Moscow, Russia.ORCID 0000-0003-2719-7133
Elena S TrofimchukDepartment of High-Molecular Compounds, Lomonosov Moscow State University, GSP-1, 1-3 Leninskiye Gory, 119991 Moscow, Russia.ORCID 0000-0002-8035-7872
Katia BarbaroIstituto Zooprofilattico Sperimentale Lazio e Toscana "M. Aleandri", Via Appia Nuova 14111, 00178 Rome, Italy.ORCID 0000-0001-9830-996X
Viktoriya G YankovaDepartment of Analytical, Physical and Colloid Chemistry, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of Ministry of Health of the Russian Federation (Sechenovskiy University), Trubetskaya 8, Build. 2, 119048 Moscow, Russia.
Iulian V AntoniacFaculty of Material Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, District 6, 060042 Bucharest, Romania.ORCID 0000-0003-0112-3494
Valery I PutlayevChemistry Department, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia.
Julietta V RauDepartment of Analytical, Physical and Colloid Chemistry, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of Ministry of Health of the Russian Federation (Sechenovskiy University), Trubetskaya 8, Build. 2, 119048 Moscow, Russia.ORCID 0000-0002-7953-1853
Vicentiu SaceleanuFaculty of Medicine, University Lucian Blaga Sibiu, 2A Lucian Blaga Street, 550169 Sibiu, Romania.ORCID 0000-0002-4997-2690

Funding

Ministry of Science and Education of the Russian Federation 075-00319-25-00
6 · The paper itself

Abstract

Bone tissue restoration requires biomaterials, which combine osteoinductivity and the capability to prevent surgical site infections. Magnesium-substituted biphasic calcium phosphate (Mg-BCP) represents a promising solution, as magnesium substitution increases the biodegradation rate of calcium phosphate ceramics and provides inherent antibacterial properties. This study aimed to achieve wet precipitation synthesis of magnesium-substituted (1-10 mol%) biphasic calcium phosphate and to evaluate its drug delivery potential and antibacterial performance. Porous Mg-BCP granules were fabricated via the gelation of Mg-BCP suspension in sodium alginate followed by polymer removal. Drug delivery potential was evaluated using methylene blue as a model compound, with methylcellulose encapsulation implemented to ensure prolonged release. Magnesium content directly ruled the phase composition: low concentrations (1%) favored hydroxyapatite phase prevalence, while higher concentrations led to the β-tricalcium phosphate formation. Further assessment of drug delivery potential revealed that direct drug loading resulted in burst release, whereas methylcellulose encapsulation successfully enabled prolonged drug delivery. Mg-5BCP formulation demonstrated significant antimicrobial activity with growth inhibition of 17.7 ± 4.1% against

Indexed as

antibacterial drug deliveryantimicrobial propertiesbiphasic calcium phosphatebone tissue engineeringmagnesium-substituted calcium phosphatemethylcellulose composite

Identifiers

PMID40942340
PMCPMC12431622

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