Evidence map›Paper›PMID 40942324›Full record

ArticlePolymers2025

Preparation and Characterization of Copper-Crosslinked Alginate-Hyaluronic Acid Aerogels as Potential Wound Dressing Materials with Enhanced Antibacterial Properties.

Tamara Athamneh, Mohammad A A Al-Najjar, Raghad Garafat, Alaa Mahmood Abuawad, Areen Alshweiat, Muna Barakat, Wael Fatehi Abu-Irmaileh, Adel Maher Hamdan, Tasneem Ali Odat, Razan Altarabeen and 2 more

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tamara AthamnehInstitute of Nanotechnology, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0000-0003-2364-5816
Mohammad A A Al-NajjarDepartment of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University (ASU), Amman 11937, Jordan.ORCID 0000-0003-4861-1604
Raghad GarafatInstitute of Nanotechnology, Jordan University of Science and Technology, Irbid 22110, Jordan.
Alaa Mahmood AbuawadDepartment of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University (ASU), Amman 11937, Jordan.
Areen AlshweiatDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa 13133, Jordan.ORCID 0000-0001-7008-0972
Muna BarakatDepartment of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University (ASU), Amman 11937, Jordan.ORCID 0000-0002-7966-1172
Wael Fatehi Abu-IrmailehQuatro-P4 Company for Industrial and Commercial Investment, Amman 11947, Jordan.
Adel Maher HamdanQuatro-P4 Company for Industrial and Commercial Investment, Amman 11947, Jordan.
Tasneem Ali OdatInstitute of Nanotechnology, Jordan University of Science and Technology, Irbid 22110, Jordan.
Razan AltarabeenInstitute of Thermal Separation Processes, Hamburg University of Technology, Eissendorfer Strasse 38, 21073 Hamburg, Germany.ORCID 0000-0002-6012-4879
Yamen Bani YounesDepartment of Psychology, University of California Los Angeles, Los Angeles, CA 90095-1563, USA.
Irina SmirnovaInstitute of Thermal Separation Processes, Hamburg University of Technology, Eissendorfer Strasse 38, 21073 Hamburg, Germany.ORCID 0000-0003-4503-4039

Funding

Jordan University of Science and Technology 20220193
6 · The paper itself

Abstract

The development of advanced wound dressing materials with enhanced antibacterial properties is critical for improving patient outcomes and reducing infection risks. This study introduces a novel bio-based aerogel composed of copper-crosslinked alginate and hyaluronic acid, synthesized using supercritical gel drying techniques. Alginate and hyaluronic acid polymers are widely used in the pharmaceutical and medical industries because of their nontoxicity, biodegradability, and biocompatibility. This study aimed to create an aerogel that could be used as a potential wound dressing material by crosslinking hyaluronic acid and alginate with copper. The bio-based aerogel was prepared by ionic gelation and supercritical gel drying. The prepared materials were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), BET surface area analysis, and energy-dispersive X-ray fluorescence (XRF). Moreover, the aerogel wound dressing properties were evaluated in terms of fluid uptake and antibacterial activity against

Indexed as

antibacterial aerogelcopperhyaluronic acid–alginate compositewound healing

Identifiers

PMID40942324
PMCPMC12431105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.