Evidence map›Paper›PMID 40942220›Full record

ArticlePolymers2025

Additive Manufacturing of Regorafenib Tablets: Formulation Strategies and Characterization for Colorectal Cancer.

Fatemeh Safari, Azin Goudarzi, Hossein Abolghasemi, Hussein Abdelamir Mohammad, Mohammad Akrami, Saeid Mohammadi, Ismaeil Haririan

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatemeh SafariSchool of Chemical Engineering, Alborz Campus, University of Tehran, Tehran 1417935840, Iran.
Azin GoudarziDepartment of Biotechnology & Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran 1417935840, Iran.ORCID 0009-0007-8019-8617
Hossein AbolghasemiCenter for Separation Processes Modeling and Nano-Computations, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran 1417935840, Iran.
Hussein Abdelamir MohammadDepartment of Pharmaceutics, College of Pharmacy, University of Al-Qadisiyah, Al Diwaniyah 58002, Iraq.
Mohammad AkramiDepartment of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.ORCID 0000-0002-4706-9385
Saeid MohammadiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran 1417614411, Iran.ORCID 0000-0002-4257-0963
Ismaeil HaririanDepartment of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.

Funding

Tehran University of Medical Sciences 67035-220-2-1402
6 · The paper itself

Abstract

Significant efforts have been dedicated to developing controlled-release systems for the effective management of colorectal cancer. In this study, a once-daily, delayed-release regorafenib (REG) tablet was fabricated using 3D printing technology for the treatment of colorectal cancer. For this, a hydrogel containing 80 mg of the drug in a matrix of hyaluronic acid, carboxymethyl cellulose, Pluronic F127, and glycerol was prepared to incorporate into the shell cavity of tablet via a pressure-assisted microsyringe (PAM). The shell was printed from an optimized ink formulation of Soluplus

Indexed as

3D printingcolorectal cancerkineticoral deliveryregorafenibreleasetablet

Identifiers

PMID40942220
PMCPMC12431445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.