Regioselective Pd-Catalyzed Hydroalkynylation of Allenyl-Containing α-Amino Acid Derivatives with Terminal Alkynes.

Alexandra S Bubnova, Daria V Vorobyeva, Ivan A Godovikov, Anna N Philippova, Pavel S Gribanov, Evgenia P Antoshkina, Sergey N Osipov

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Alexandra S BubnovaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.ORCID 0000-0003-0731-9156

Daria V VorobyevaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.

Ivan A GodovikovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.

Anna N PhilippovaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.

Pavel S GribanovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.ORCID 0000-0003-3820-5442

Evgenia P AntoshkinaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.

Sergey N OsipovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.ORCID 0000-0001-5625-776X

Funding

Russian Science Foundation 25-13-00209

6 · The paper itself

Abstract

An efficient access to the novel representatives of α,α-disubstituted α-amino acids with 1,3-enyne unit located at their side chain has been elaborated. The method is based on Pd(II)-catalyzed hydroalkynylation of α-allenyl-α-dimethylamino esters with terminal acetylenes. The developed strategy is the first example of the metal-catalyzed allene-alkyne coupling to provide a convenient route to new unsaturated α-amino acid derivatives in good yields and high selectivity.

Indexed as

1,3-enynesalkynesallenescatalysishydroalkynylation

Identifiers

PMID40942148

DOI10.3390/molecules30173623

PMCPMC12430138

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