Unlocking New Potential in the Functionalization of Chlorinated Silsesquioxanes: A Rapid and Chemoselective Thiolation Method.

Niyaz Yagafarov, Yujia Liu, Naoto Adachi, Nobuhiro Takeda, Masafumi Unno, Armelle Ouali

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Niyaz YagafarovDepartment of Chemistry and Chemical Biology, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan.

Yujia LiuDepartment of Chemistry and Chemical Biology, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan.ORCID 0000-0002-3610-6355

Naoto AdachiDepartment of Chemistry and Chemical Biology, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan.

Nobuhiro TakedaDepartment of Chemistry and Chemical Biology, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan.ORCID 0000-0001-5732-758X

Masafumi UnnoDepartment of Chemistry and Chemical Biology, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan.ORCID 0000-0003-2158-1644

Armelle OualiICGM, Univ Montpellier, CNRS, ENSCM, (Institut Charles Gerhardt Montpellier, Université de Montpellier, Centre National de la Recherche Scientifique, École Nationale Supérieure de Chimie de Montpellier), 1919 Route de Mende, CEDEX 05, 34293 Montpellier, France.

Funding

CNRS International Research Project SiliconNanoCat, between the Charles Gerhardt Institute and Gunma UniversityNew Energy and Industrial Technology Development Organization project No. JPNP06046

6 · The paper itself

Abstract

A highly efficient method was successfully applied for the first time to the functionalization of well-defined chlorinated silsesquioxanes with a range of thiols. Thiolation was rapid (2 to 4 h), quantitative, with complete conversion of the reactants and full chemoselectivity, and proceeded under mild conditions (room temperature). This "click chemistry" approach facilitated the preparation of nine novel compounds, with good to excellent isolated yields (64-92%). The structures and purities of these compounds were comprehensively confirmed using multiple analytical techniques, including

Indexed as

click chemistrymild organic transformationnucleophilic substitutionthiolationwell-defined chlorinated silsesquioxanes

Identifiers

PMID40942108

DOI10.3390/molecules30173583

PMCPMC12430186

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