Recent Advances in Octacalcium Phosphate with Incorporated Carboxylate Ions: A Review.

Octacalcium phosphate (OCP) is a calcium phosphate compound with a layered structure in which apatite layers, which have a structure similar to hydroxyapatite, and hydrated layers are stacked alternately. OCP can incorporate various carboxylate ions into its interlayers. OCPs with incorporated carboxylate ions, also known as OCP carboxylates (OCPCs), are organically modified at the molecular level. OCPCs are an attractive research target in a wide range of fields, from basic inorganic chemistry to applied materials chemistry. Therefore, it is expected that a comprehensive overview of recent research on OCPCs will be useful in progressing this field. This review focuses on recent advances in OCPCs, namely their synthesis, the identification of new types of carboxylate ions that can be incorporated into OCP interlayers, the steric structure estimation of the interlayer carboxylate ions, and applications of OCPCs as functional materials. OCPC-based functional materials include fluorescent materials, artificial bones, and adsorbents. Furthermore, based on existing studies, challenges in OCPC research and future research directions are described.