Evidence map›Paper›PMID 40942032›Full record

ReviewMolecules (Basel, Switzerland)2025

Review of Modern Eschweiler-Clarke Methylation Reaction.

Xiaoli Zhou, Xue Ni, Xianfu Wu, Lihui Yin

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaoli ZhouNational Institutes for Food and Drug Control, Beijing 102629, China.ORCID 0000-0002-3411-4335
Xue NiNational Institutes for Food and Drug Control, Beijing 102629, China.
Xianfu WuNational Institutes for Food and Drug Control, Beijing 102629, China.
Lihui YinNational Institutes for Food and Drug Control, Beijing 102629, China.ORCID 0009-0005-3455-0216

Funding

National Institutes for Food and Drug Control GJJS-2022-5-2
6 · The paper itself

Abstract

This paper reviews a substantial amount of research related to the Eschweiler-Clarke methylation reaction, summarizing its mechanism, development, and applications, to present the chemical essence and history of this reaction and its importance and application in modern synthetic chemistry. In particular, this review focuses on advances regarding the Eschweiler-Clarke methylation reaction since 2000. This work will provide researchers with a comprehensive and in-depth perspective of the Eschweiler-Clarke reaction, as well as guidance and inspiration for future research and application.

Indexed as

amineEschweiler–Clarkeformaldehydeformic acidmethylation

Identifiers

PMID40942032
PMCPMC12430128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.