Evidence map›Paper›PMID 40941995›Full record

ReviewMolecules (Basel, Switzerland)2025

A Comprehensive Review of Niosomes: Composition, Structure, Formation, Characterization, and Applications in Bioactive Molecule Delivery Systems.

Alfredo Amaury Bautista-Solano, Gloria Dávila-Ortiz, María de Jesús Perea-Flores, Alma Leticia Martínez-Ayala

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alfredo Amaury Bautista-SolanoDepartamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Av. Wilfrido Massieu Esq. Miguel Stampa s/n, Zacatenco, Alcaldía Gustavo A. Madero, Ciudad de Mexico 07728, Mexico.ORCID 0000-0002-9742-113X
Gloria Dávila-OrtizDepartamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Av. Wilfrido Massieu Esq. Miguel Stampa s/n, Zacatenco, Alcaldía Gustavo A. Madero, Ciudad de Mexico 07728, Mexico.ORCID 0000-0001-8235-1960
María de Jesús Perea-FloresCentro de Nanociencias y Micro y Nanotecnologías, Instituto Politécnico Nacional (IPN), Unidad Profesional Adolfo López Mateos, Av. Luis Enrique Erro s/n, Zacatenco, Alcaldía Gustavo A. Madero, Ciudad de Mexico 07738, Mexico.ORCID 0000-0002-0441-9891
Alma Leticia Martínez-AyalaDepartamento de Biotecnología, Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional (IPN), Carretera Yautepec-Jojutla s/n-km 85, San Isidro 62739, Morelos, Mexico.ORCID 0000-0001-9875-4086

Funding

Instituto Politécnico Nacional 20250008Instituto Politécnico Nacional 20250039Instituto Politécnico Nacional 20250683
6 · The paper itself

Abstract

Niosomes are nanocarriers with a bilayer structure, consisting of a polar region and a non-polar region. This unique structure allows them to encapsulate compounds with varying polarities, addressing solubility challenges in the transport and delivery of bioactive molecules. The formation of niosomes involves key structural, geometric, and thermodynamic factors influenced by the choice of surfactants and preparation methods. These factors, including the critical packing factor and the hydrophilic-lipophilic balance (HLB), play a crucial role in determining the properties of the final niosomes. Additionally, the use of Tandford's equations allows for the calculation of geometric parameters. These factors determine the structural integrity and functional properties of niosomes, making it possible to design functional niosomes with characteristics tailored for specific applications. This ability to design niosomes with desired properties is especially valuable in biomedical fields, where precise control over drug delivery and targeting is essential. This review highlights the importance of niosome formulation and presents examples of niosomes that have been functionalized for specific applications, including anticancer treatments, immunological treatments, and their action in the central nervous system.

Indexed as

Drug CarriersDrug Delivery SystemsLiposomesAnimalsHumansHydrophobic and Hydrophilic InteractionsSurface-Active AgentsDrug CarriersLiposomesSurface-Active Agentsdrug deliverynanotransportersniosome compositionniosome formationniosomes

Identifiers

PMID40941995
PMCPMC12429857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.