Evidence map›Paper›PMID 40941257›Full record

ReviewFoods (Basel, Switzerland)2025

Functional Ingredients: From Molecule to Market-AI-Enabled Design, Bioavailability, Consumer Impact, and Clinical Evidence.

Lei Zhao, Wen-Ming Ju, Lin-Lin Wang, Yu-Bin Ye, Zheng-Yang Liu, George Cavender, Yong-Jun Sun, Sheng-Qian Sun

Abstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Bioactive Fraction LCS2 from Litchi (Foods (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lei ZhaoSchool of Food and Biological Engineering, Yantai Institute of Technology, Yantai 264003, China.
Wen-Ming JuShandong Homey Aquatic Development Co., Ltd., Weihai 264300, China.
Lin-Lin WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100085, China.
Yu-Bin YeHubei Juneyao Health Beverage Co., Ltd. (Juneyao Health), Shanghai 201315, China.
Zheng-Yang LiuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100085, China.
George CavenderDepartment of Food, Nutrition and Packaging Sciences, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-3857-0717
Yong-Jun SunShandong Homey Aquatic Development Co., Ltd., Weihai 264300, China.
Sheng-Qian SunSchool of Food and Biological Engineering, Yantai Institute of Technology, Yantai 264003, China.ORCID 0000-0002-6030-3455

Funding

The Industry-Academia Collaborative Program of the Ministry of Education 22097155283227The Science and Technology Project of the State Administration for Market Regulation of China No. 2024MK078Yantai Institute of Technology Scientific Applied Curriculum Development Project 2023YYK20Yantai Institute of Technology Scientific Research and Innovation Fund for High-level Talents RC20SP001Yantai Science and Technology Bureau Support Grant/Science and Technology Innovation Development Project 2022XDRH034
6 · The paper itself

Abstract

Functional ingredients such as dietary fibers, probiotics and prebiotics, polyphenols, omega-3 fatty acids, and bioactive peptides are increasingly central to food systems that aim to deliver health benefits beyond basic nutrition. This review explores how molecular structure, physicochemical properties, metabolism, and microbiome interactions affect bioactivity and bioavailability. We highlight advances in green extraction, encapsulation technologies, and 3D/4D printing that enhance the stability and targeted delivery of bioactives. AI-enabled tools for ingredient discovery, structure-activity modeling, and personalized formulation are also discussed. Sensory research and market insights inform strategies to improve consumer acceptance, while clinical studies provide evidence for cardiometabolic, immune, and cognitive benefits. Safety and regulatory aspects are addressed, particularly for emerging proteins and delivery systems. By integrating scientific and technological developments across disciplines, this review provides a comprehensive foundation for future research and commercialization of safe, effective, and personalized functional food products.

Indexed as

bioavailabilitycommercial valuefunctional ingredientshealth effectpersonalized nutrition

Identifiers

PMID40941257
PMCPMC12428546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.