Evidence map›Paper›PMID 40941146›Full record

ArticleFoods (Basel, Switzerland)2025

Eco-Friendly Extraction of Olive Leaf Phenolics and Terpenes: A Comparative Performance Analysis Against Conventional Methods.

Lucía López-Salas, Xavier Expósito-Almellón, Anderson Valencia-Isaza, Alejandro Fernández-Arteaga, Rosa Quirantes-Piné, Isabel Borrás-Linares, Jesús Lozano-Sánchez

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Influence of Ultrasound-Assisted and Supercritical COMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucía López-SalasDepartment of Food Science and Nutrition, University of Granada, Campus Universitario s/n, 18071 Granada, Spain.ORCID 0009-0006-5683-2238
Xavier Expósito-AlmellónDepartment of Food Science and Nutrition, University of Granada, Campus Universitario s/n, 18071 Granada, Spain.ORCID 0009-0004-1829-0285
Anderson Valencia-IsazaDepartment of Chemical Engineering, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.ORCID 0000-0003-1914-8489
Alejandro Fernández-ArteagaDepartment of Chemical Engineering, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.ORCID 0000-0002-5407-7877
Rosa Quirantes-PinéDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.ORCID 0000-0002-2107-6333
Isabel Borrás-LinaresDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.ORCID 0000-0002-5227-9002
Jesús Lozano-SánchezDepartment of Food Science and Nutrition, University of Granada, Campus Universitario s/n, 18071 Granada, Spain.ORCID 0000-0001-8769-3070

Funding

Spanish Ministry of Science and Innovation TED2021-132489A-I00
6 · The paper itself

Abstract

The present study focuses on recovering phenolic compounds and terpenes from olive leaves, which are generated as by-products during olive oil processing. To this end, conventional extraction/maceration (CE) and advanced extraction techniques such as subcritical water extraction (SWE), pressurized fluid extraction (PLE) and ultrasound-assisted extraction (UAE) were employed to compare and determine the most effective procedure. The phenolic and terpenoid composition of the extracts revealed a total of 33 compounds in HPLC-QTOF-MS analysis. According to these findings, the optimal extraction techniques for the maximum recovery of secoiridoids from olive leaves were PLE and UAE, with no significant difference between them (21.9891 ± 2.5521 mg/g DW and 21.0888 ± 1.3494 mg/g DW, respectively). Regarding to flavonoids, UAE was the most effective extraction technique, yielding 4.9837 ± 0.6739 mg/g DW. However, SWE recovered the highest amount of phenolic alcohols (7.4201 ± 0.9848 mg/g DW), which could be due to degradation of the secoiridoids during extraction. Conversely, UAE was more successful than the other techniques for the extraction of the terpene family (0.7373 ± 0.0601 mg/g DW). The present study therefore focuses on comparing different extraction techniques for revalorizing olive leaves as a source of bioactive compounds, specifically polyphenols and terpenes, due to their beneficial health properties.

Indexed as

HPLC-MSOlea europaea L.olive leavesolive wastepolyphenolsterpenic compounds

Identifiers

PMID40941146
PMCPMC12428601

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.