Evidence map›Paper›PMID 40941037›Full record

ReviewCancers2025

Unlocking the Potential of Immune Checkpoint Inhibitors in HR+/HER2- Breast Cancer: A Systematic Review.

Giuseppe Di Grazia, Arianna Dri, Angela Grieco, Claudia Martinelli, Michela Palleschi, Federica Martorana, Giacomo Barchiesi, Grazia Arpino, Carmine De Angelis, Michelino De Laurentiis and 4 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Cancers · 2026
    Review
  2. Review
  3. Article
  4. Evaluation of targeted and immune combination therapies in a rat model of hormone receptor-positive breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giuseppe Di GraziaSchool of Specialization in Medical Oncology, Department of Human Pathology "G. Barresi", Azienda Ospedaliera Universitaria Policlinico "G. Martino", University of Messina, Via Consolare Valeria N. 1, Gazzi, 98125 Messina, Italy.ORCID 0009-0001-6147-9655
Arianna DriDepartment of Medicine (DMED), University of Udine, 33100 Udine, Italy.ORCID 0000-0002-6992-301X
Angela GriecoDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
Claudia MartinelliDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
Michela PalleschiMedical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0003-2623-4705
Federica MartoranaDepartment of Clinical and Experimental Medicine, University of Catania, Torre Biologica "F. Latteri"-lato nord-p. 9 via Santa Sofia, 89, 95123 Catania, Italy.ORCID 0000-0001-5062-2914
Giacomo BarchiesiUOC Oncologia A, Azienda Ospedaliero-Universitaria Policlinico Umberto I, 00161 Roma, Italy.
Grazia ArpinoDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-4074-2530
Carmine De AngelisScuola Superiore Meridionale, Via Mezzocannone, 4, 80134 Napoli, Italy.ORCID 0000-0003-1158-4630
Michelino De LaurentiisIstituto Nazionale Tumori IRCCS Fondazione G Pascale, 80131 Naples, Italy.
Lucia Del MastroIRCSS Ospedale Policlinico San Martino, UO Breast Unit, 16121 Genoa, Italy.ORCID 0000-0002-9546-5841
Fabio PuglisiDepartment of Medicine (DMED), University of Udine, 33100 Udine, Italy.ORCID 0000-0003-0573-4938
Paolo VigneriDepartment of Clinical and Experimental Medicine, University of Catania, Torre Biologica "F. Latteri"-lato nord-p. 9 via Santa Sofia, 89, 95123 Catania, Italy.ORCID 0000-0002-5943-6066
Mario GiulianoDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkersclinical trialsHR+/HER2− breast cancerimmune checkpoint inhibitors

Identifiers

PMID40941037
PMCPMC12428055

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.