Evidence map›Paper›PMID 40941016›Full record

ReviewCancers2025

An Update on Single-Cell RNA Sequencing in Illuminating Disease Mechanisms of Cutaneous T-Cell Lymphoma.

Sara Suhl, Alexander Kaminsky, Caroline Chen, Brigit A Lapolla, Maggie H Zhou, Joshua Kent, Abigail Marx, Ikenna David Nebo, Geat Ramush, Sophia Luyten and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sara SuhlVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-4535-0082
Alexander KaminskyVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-0059-2619
Caroline ChenVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Brigit A LapollaDepartment of Dermatology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Maggie H ZhouVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Joshua KentDepartment of Dermatology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0009-0004-7297-4469
Abigail MarxVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Ikenna David NeboVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0009-0006-9189-7483
Geat RamushVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Sophia LuytenVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Yoni SacknovitzVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Julie SungDepartment of Dermatology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Christina M BearVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Celine M SchreidahDepartment of Dermatology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Alejandro GruDepartment of Dermatology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Larisa J GeskinDepartment of Dermatology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous T-cell Lymphomas (CTCLs) are a heterogeneous group of non-Hodgkin lymphomas that currently have an incompletely understood pathophysiology and several challenges in both diagnosis and management. Single-cell RNA sequencing (scRNA-seq) is a powerful tool that enables the analysis of gene expression at the individual-cell level, revealing cellular heterogeneity and a complex tumor microenvironment. As single-cell RNA sequencing has become increasingly utilized, we aimed to provide an update on recent notable applications of single-cell RNA sequencing in CTCL and their findings. The included studies highlight the intricate network of interactions in the tumor microenvironment that contributes to tumorigenesis. While CTCL is notoriously heterogeneous, our results identify key markers that prove promising for diagnosis, prognostication, and therapeutic targets.

Indexed as

biomarkersCTCLcutaneous T-cell lymphomagenomicmycosis fungoidesscRNA-seqSézary syndromesingle-cell RNA sequencingtranscriptomictumor microenvironment

Identifiers

PMID40941016
PMCPMC12427944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.