Evidence map›Paper›PMID 40940966›Full record

ReviewCancers2025

Histopathological, Immunohistochemical, Molecular and Genetic Biomarkers in Differentiated Thyroid Cancer.

Mousa A Al-Abbadi, Dunia Aburizeg, Husam Abuawad, Hala Alzaghloul, Omar Sqour, Bilal Azab, Tala Qudisat, Ali M Alabbadi, Ayman Mismar, Malik Eid Juweid

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mousa A Al-AbbadiDepartment of Histopathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Amman 11942, Jordan.
Dunia AburizegDepartment of Histopathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Amman 11942, Jordan.ORCID 0009-0005-8311-1850
Husam AbuawadDepartment of Histopathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Amman 11942, Jordan.ORCID 0009-0000-0765-1517
Hala AlzaghloulSchool of Medicine, University of Jordan, Amman 11942, Jordan.ORCID 0009-0008-0724-9593
Omar SqourSchool of Medicine, University of Jordan, Amman 11942, Jordan.
Bilal AzabDepartment of Histopathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Amman 11942, Jordan.
Tala QudisatSchool of Medicine, University of Jordan, Amman 11942, Jordan.ORCID 0009-0002-9688-0681
Ali M AlabbadiDepartment of Radiology and Nuclear Medicine, School of Medicine, University of Jordan, Amman 11942, Jordan.
Ayman MismarDepartment of General Surgery, Jordan University Hospital, Amman 11942, Jordan.
Malik Eid JuweidDepartment of Radiology and Nuclear Medicine, School of Medicine, University of Jordan, Amman 11942, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiated thyroid cancer (DTC) is the most prevalent endocrine malignancy in the world. Accurate diagnosis and prognostication are essential for optimizing its treatment and improving patient outcomes. This narrative review explores the diagnostic and prognostic histopathological, immunohistochemical, molecular, and genetic biomarkers in DTC, emphasizing their role in risk stratification and personalized management. Histopathological biomarkers, including tumor size, extrathyroidal extension, lymphovascular invasion, and aggressive subtypes (e.g., tall cell, hobnail, and insular variants), correlate with poor prognosis. Additionally, genetic alterations such as

Indexed as

histopathological immunohistochemical molecular, and geneticreviewthyroid cancer biomarkers

Identifiers

PMID40940966
PMCPMC12427551

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.