ArticleCancers2025
Two Decades of Outcomes and Quality of Life Following Pencil Beam Scanning Proton Therapy in Children and Adolescents with Rhabdomyosarcoma.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- What's new in pediatric bone sarcomas and benign bone tumors.Journal of children's orthopaedics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRMS is the most common soft tissue sarcoma in children. Pencil beam scanning proton therapy (PBS PT) enables highly conformal dose delivery with reduced exposure to surrounding healthy structures, making it particularly suited for RMS in critical anatomical regions. Long-term clinical outcome data for this new radiation technique are scarce. PURPOSE: This study reports long-term outcomes and quality of life after PBS PT in children and adolescents with rhabdomyosarcoma (RMS). METHODS AND MATERIALS: We retrospectively reviewed 114 children and adolescents with RMS (mostly embryonal,
resultsAfter a median follow-up period of 7.1 years (range, 0.3 to 17 years), we observed 26 failures overall; 21 (80.8%) occurred in-field. The 5-year local control and overall survival were 81.2% and 81%, respectively. The composite endpoint (non-ocular grade ≥3 toxicity- and failure-free survival) counting the first occurrence of any failure (local or distant), death, or non-ocular CTCAE v5.0 grade ≥3 toxicity was 77.3% at 5 years. At the start of PT, parents and children reported a quality of life significantly worse than that of a German normative group, but during the follow-up period, their scores improved to normal values in nearly all domains within two years.
conclusionsOur two decades of experience with PBS PT provide data that reflect good local control rates and minimal late non-ocular grade 3 toxicity. We also show that quality of life returned to normal scores in nearly all domains within 2 years. Children and adolescents with RMS seem to benefit from PBS PT in terms of toxicity and quality of life, but further prospective, multi-institutional comparative trials are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.