Evidence map›Paper›PMID 40940797›Full record

ArticleCells2025

Efficacy of Conventional and Novel Tyrosine Kinase Inhibitors for Uncommon

Hana Oiki, Kenichi Suda, Akira Hamada, Toshio Fujino, Keiko Obata, Yoshihisa Kobayashi, Kazuko Sakai, Shota Fukuda, Shuta Ohara, Masaoki Ito and 4 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hana OikiDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0009-0008-9384-5577
Kenichi SudaDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0000-0002-0842-8832
Akira HamadaDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0000-0003-1689-9447
Toshio FujinoDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.
Keiko ObataDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.
Yoshihisa KobayashiDivision of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Kazuko SakaiDepartment of Genome Biology, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.
Shota FukudaDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0000-0003-3522-834X
Shuta OharaDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0000-0002-9159-8743
Masaoki ItoDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.
Junichi SohDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0000-0001-8532-7915
Kazuto NishioDepartment of Genome Biology, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0000-0002-8275-0846
Tetsuya MitsudomiDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.
Yasuhiro TsutaniDivision of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.ORCID 0000-0001-8836-1027

Funding

Japan Society for the Promotion of Science 22K07291 / 23K15569 / 22K08986
6 · The paper itself

Abstract

Afatinib and osimertinib are current treatment options for non-small cell lung cancer (NSCLC) patients with uncommon epidermal growth factor receptor (

Indexed as

MutationProtein Kinase InhibitorsAcrylamidesAfatinibAniline CompoundsAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorCell ProliferationDrug Resistance, NeoplasmErbB ReceptorsHumansIndolesLung NeoplasmsPyrimidinesTyrosine Kinase InhibitorsAcrylamidesAfatinibAniline CompoundsEGFR protein, humanErbB ReceptorsIndolesosimertinibProtein Kinase InhibitorsPyrimidinesTyrosine Kinase Inhibitorsacquired resistanceafatinibBa/F3 cellslazertinibmolecular targeted therapiesosimertinibpersonalized treatmenttyrosine kinase inhibitorsuncommon mutation

Identifiers

PMID40940797
PMCPMC12427748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.