Evidence map›Paper›PMID 40940771›Full record

ArticleCells2025

Impact of Donor and Host Age on Systemic Cell Therapy to Treat Age-Related Macular Degeneration.

Carolina Francelin, Xiaoping Qi, Juliana Godoy, Brenton T Bicknell, Ram Prasad, Maria B Grant, Michael E Boulton

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carolina FrancelinDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-7439-3124
Xiaoping QiDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0009-0009-6768-405X
Juliana GodoyDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-1276-4297
Brenton T BicknellDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0009-0000-2101-2543
Ram PrasadDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-1931-5040
Maria B GrantDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Michael E BoultonDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-0796-1766

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
NITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6M
LXR as a Novel Therapeutic Target in Diabetic RetinopathyR01EY025383 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUSIK, JULIA V, GRANT, MARIA BARTOLOMEO · 2015 to 2024
$4.2M
Brain-gut-retina axis in diabetic retinopathyR01EY033620 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHARLES J FRAZIER, Maria Bartolomeo Grant · 2023 to 2026
$2.1M
Somatostatin blockade of CNS autonomic hyperactivity for treatment of diabetic retinopathyR01EY028037 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, FRAZIER, CHARLES J · 2017 to 2020
$1.9M
ACE2 on gut barrier dysfunction and BRB disruptionR01EY032753 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael Edwin Boulton, Maria Bartolomeo Grant · 2022 to 2026
$1.8M
Endothelial Rap1 restricts inflammation in the retinaR01EY036588 · NEI · VERSITI WISCONSIN, INC. · PI Magdalena Chrzanowska, Maria Bartolomeo Grant · 2024 to 2026
$1.8M
ACE2 Modulates the Bone Marrow- Gut Axis in Diabetic RetinopathyR01EY028858 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2018 to 2021
$1.6M
NCI NIH HHS P30 CA013148NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY012601NEI NIH HHS R01EY012601NEI NIH HHS R01 EY025383NEI NIH HHS R01 EY028037NEI NIH HHS R01 EY028858NEI NIH HHS R01 EY032753NEI NIH HHS R01 EY033620NEI NIH HHS R01EY036588NIAID NIH HHS P30 AI027767
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingCell- and Tissue-Based TherapyMacular DegenerationAge FactorsAnimalsDisease Models, AnimalHematopoietic Stem CellsMiceMice, Inbred C57BLRetinaRetinal Pigment EpitheliumSuperoxide DismutaseSuperoxide Dismutase 2Superoxide DismutaseSuperoxide Dismutase 2age-related macular degenerationagingbone marrow-derived cellsgene therapyhematopoietic stem cellsprogenitorsretinal degenerationretinal pigment epitheliumRPE65

Identifiers

PMID40940771
PMCPMC12427682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.