Evidence map›Paper›PMID 40940756›Full record

Observational studyCells2025

Endocrine Disruption as a Mediator of Declining Semen Quality in Smokers.

Birupakshya Paul Choudhury, Sandipan Das, Kushal Kumar Kar, Petr Slama, Adriana Kolesarova, Israel Maldonado Rosas, Shubhadeep Roychoudhury

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Birupakshya Paul ChoudhuryDepartment of Life Science and Bioinformatics, Assam University, Silchar 788011, India.
Sandipan DasDepartment of Life Science and Bioinformatics, Assam University, Silchar 788011, India.ORCID 0000-0003-2596-3674
Kushal Kumar KarMediland Hospital and Research Centre, Silchar 788002, India.
Petr SlamaLaboratory of Animal Immunology and Biotechnology, Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, 61300 Brno, Czech Republic.ORCID 0000-0003-0570-259X
Adriana KolesarovaAgroBioTech Research Centre, Slovak University of Agriculture in Nitra, 949 76 Nitra, Slovakia.
Israel Maldonado RosasCitmer Reproductive Medicine, Mexico City 11520, Mexico.ORCID 0000-0003-2765-6176
Shubhadeep RoychoudhuryDepartment of Life Science and Bioinformatics, Assam University, Silchar 788011, India.ORCID 0000-0003-4174-1852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCigarette smoking is one of the most common lifestyle and environmental risk factors for male infertility. Although smoking has been implicated in male fertility decline, the association between endocrine disruption and semen quality reduction remains underexplored in smokers. This study demonstrates the impact of reproductive hormones on the modulation of semen quality in infertile men.

methodsEighty infertile men participated in this observational study. They were interviewed for environment and lifestyle factors, following which their semen and four reproductive hormones, viz, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and testosterone, were analyzed. A comparative analysis between non-smokers and smokers highlighted notable differences in hormone levels and semen quality. To explore the relationships between reproductive hormones and semen quality parameters, correlation and multiple linear regression analyses were conducted.

resultsSmokers exhibited a lower percentage of live sperm (

conclusionCigarette smoking disrupts the regulation of reproductive hormones, which further impacts semen quality. This study provides insights into the potential impact of smoking on semen quality through hormonal mechanisms.

Indexed as

Endocrine DisruptorsInfertility, MaleSemenSemen AnalysisSmokersSmokingAdultFollicle Stimulating HormoneHumansLuteinizing HormoneMaleProlactinSpermatozoaSperm CountTestosteroneEndocrine DisruptorsFollicle Stimulating HormoneLuteinizing HormoneProlactinTestosteronecigarette smokinghormonal regulationmale infertilitymultiple linear regressionreproductionreproductive hormonessperm quality

Identifiers

PMID40940756
PMCPMC12428148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.