Evidence map›Paper›PMID 40940739›Full record

ReviewCells2025

DNA Methylation: A Potential Mediator of the Memory Regulatory Effects of taVNS.

Pak On Patrick Yee, Ka Chun Tsui, Man Lung Fung, Boon Chin Heng, Ersoy Kocabicak, Ali Jahanshahi, Yasin Temel, Arjan Blokland, Luca Aquili, Allan Kalueff and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pak On Patrick YeeDrLim Neuromodulation Lab, Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.ORCID 0009-0007-4491-8445
Ka Chun TsuiDrLim Neuromodulation Lab, Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.ORCID 0000-0002-1366-1284
Man Lung FungSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
Boon Chin HengSchool and Hospital of Stomatology, Peking University, Beijing 100081, China.
Ersoy KocabicakFaculty of Medicine, Atlas University, Istanbul 34408, Turkey.
Ali JahanshahiDepartment of Neurosurgery, Maastricht University, 6229 HX Maastricht, The Netherlands.
Yasin TemelDepartment of Neurosurgery, Maastricht University, 6229 HX Maastricht, The Netherlands.
Arjan BloklandDepartment of Neuropsychology and Psychopharmacology, Maastricht University, 6200 MD Maastricht, The Netherlands.
Luca AquiliDrLim Neuromodulation Lab, Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.ORCID 0000-0003-4930-1536
Allan KalueffSuzhou Key Laboratory of Neurobiology and Cell Signaling, Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.ORCID 0000-0002-7525-1950
Kah Hui WongDepartment of Anatomy, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-8292-4498
Lee Wei LimDrLim Neuromodulation Lab, Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.ORCID 0000-0001-6692-6285

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcutaneous auricular vagus nerve stimulation (taVNS), an emerging noninvasive neuromodulation technique, has shown promise for improving memory. A better understanding of the epigenetic mechanisms underlying the effects of taVNS would inform the molecular outcomes essential for memory and cognition. In this review, we synthesize the current literature on the neurophysiological and biochemical basis of taVNS. Next, we explore how DNA methylation regulators (e.g., DNA methyltransferase 3a) and readers (e.g., methyl-CpG binding protein 2) differentially regulate memory, and how their activity and expression can be regulated by neuronal activity. Finally, we describe the potential involvement of DNA methylation in mediating the memory regulatory effects of taVNS and discuss possible directions for future studies.

Indexed as

DNA MethylationMemoryVagus Nerve StimulationAnimalsEpigenesis, GeneticHumanscognitive impairmentDNA methylationmemoryneuronal activitytranscutaneous auricular vagus nerve stimulation

Identifiers

PMID40940739
PMCPMC12428552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.