Evidence map›Paper›PMID 40940726›Full record

ArticleCells2025

Calpain-1 and Calpain-2 Promote Breast Cancer Metastasis.

Danielle Harper, Jung Yeon Min, James A MacLeod, Samantha Cockburn, Iryna Predko, Yan Gao, Peter A Greer, Ivan Shapovalov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Genetic disruption ofmicroPublication biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danielle HarperDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.ORCID 0009-0009-1184-4923
Jung Yeon MinDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
James A MacLeodDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Samantha CockburnDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Iryna PredkoDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.ORCID 0009-0007-0835-833X
Yan GaoDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Peter A GreerDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Ivan ShapovalovDepartment Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L3N6, Canada.ORCID 0009-0002-3111-6770

Funding

CIHR FBD-181422CIHR PJT-166062
6 · The paper itself

Abstract

In breast cancer, progression from localized stage I to distant metastatic stage IV disease is associated with a reduction of 5-year survival from nearly 100% to 23.2%. Expression of the calcium-activated protease isoforms calpain-1 and calpain-2 has been correlated with cell migration and invasion in vitro, metastatic potential in preclinical mouse models of cancer, and breast cancer prognosis in patients. It is unclear which of these two calpain isoforms is responsible for the apparent metastatic potential of cancer cells. Here, we demonstrate that while individual CRISPR-Cas9 knockouts of either

Indexed as

Breast NeoplasmsCalpainAnimalsCell Line, TumorCell MovementFemaleHumansMiceNeoplasm MetastasisCalpainCAPN1 protein, humanCAPN2 protein, humanCAPNS1 protein, humanbreast cancercalpainCRISPR-Cas9metastasismouse model

Identifiers

PMID40940726
PMCPMC12427806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.