ArticleCells2025
High-Resolution Adaptive Optics Transscleral Flood Illumination Imaging Allows Phenotyping of Age-Related Macular Degeneration.
Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Adaptive optics transscleral flood illumination (AO-TFI) enables in vivo imaging of the retinal pigment epithelium (RPE) at near-cellular resolution. In this study, we evaluated its potential as a phenotyping tool in age-related macular degeneration (AMD) by analyzing disease-associated structural patterns and their correlation with optical coherence tomography (OCT) features. We examined AO-TFI images from 120 eyes diagnosed with either early-to-advanced dry AMD (including geographic atrophy, GA) or neovascular AMD (nvAMD). Images were graded by a masked reader, and patterns were matched to corresponding OCT findings. Four consistent morphologic patterns were identified: atrophy, pre-atrophy, soft drusen, and reticular pseudodrusen. Morphometric quantification of hyporeflective regions showed progressive changes in perimeter, diameter, and area from reticular pseudodrusen to soft drusen and pre-atrophy, returning to lower values in atrophy. Distinct nvAMD-specific signatures were not identified. AO-TFI offers a practical, high-resolution complement to OCT, AO-SLO, and AO-OCT for phenotypic characterization of AMD in clinical settings.
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