SynthesisSpine deformity2026
Long-term cancer risk in historic cohorts of patients with adolescent idiopathic scoliosis: a systematic review.
Synthesis in Spine deformity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Millimeter-Wave Imaging for Idiopathic Scoliosis Screening: Diagnostic Accuracy Study.JMIR pediatrics and parenting · 2026Article
- Article
- Cancer risk among women with scoliosis: a nationwide danish register-based study.Spine deformity · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the long-term cancer risks associated with AIS, focusing on the roles of genetic predispositions and radiation exposure.
methodsA comprehensive systematic search was conducted on August 5, 2024, across PubMed, EMBASE, Scopus, Cochrane Libraries, and CINAHL, covering studies from 1947 onward. Human studies on patients with scoliosis diagnosed before age 20 were included. For cancer assessment, both risk, incidence and mortality were included. Studies were excluded if they focused solely on congenital or secondary scoliosis. Screening and quality assessment were conducted using Covidence. The first author performed the initial screening, while the first and second authors conducted full-text assessments and quality assessment collaboratively, with an agreement score of 0.83.
resultsSeven studies from the USA, Australia, Denmark and The Netherlands were identified. Notable findings included elevated breast cancer risks among US cohorts, linked to historical radiographic practices that delivered higher radiation doses. None of the included studies assessed genetic etiologies of cancer. Risk of bias in the studies were generally attributed to selection bias and underreporting of characteristics and confounding variables. While most studies included either showed a tendency or a significant association towards an association between scoliosis and risk of cancer, it was mainly based on data before 1990 with exposure to radiation several orders of magnitude larger than modern standards. These changes could be a major factor in the risk of cancer identified in historical cohorts.
conclusionThis review highlights the importance of continued research, including the effect of modern examination techniques, such as EOS, MRI on rates of cancer in modern populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.