Evidence map›Paper›PMID 40940597›Full record

ReviewAnnals of surgical oncology2026

Molecular and Biological Features of Invasive Lobular Carcinoma: Toward New Treatment Strategies.

Nanaka Ozawa, Erina Takeyama, Honoka Sakai, Ayaka Katayama, Mai Onishi, Rika Kizawa, Yuki Matsunaga, Kazuki Nozawa, Nodoka Umezaki, Reiko Mitsueda and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nanaka OzawaDepartment of Breast Surgery, International University of Health and Welfare, Chiba, Japan.
Erina TakeyamaDepartment of Breast Surgery, International University of Health and Welfare, Chiba, Japan.
Honoka SakaiDepartment of Breast Surgery, International University of Health and Welfare, Chiba, Japan.
Ayaka KatayamaDepartment of Diagnostic Pathology, Gunma University, Gunma, Japan.
Mai OnishiDepartment of Medical Oncology, Dana-Farber Cancer Institute Harvard Medical School, Boston, MA, USA.
Rika KizawaDepartment of Breast Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Yuki MatsunagaSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kazuki NozawaDepartment of Advanced Clinical Research and Development, Graduate School of Medical Sciences, Nagoya City University, Aichi, Japan.
Nodoka UmezakiDepartment of Breast Surgery, Kansai Medical University, Osaka, Japan.
Reiko MitsuedaDepartment of Breast and Thyroid Surgical Oncology, Hakuaikai Sagara Hospital, Kagoshima, Japan.
Keiko TanabeDepartment of Breast and Endocrine Surgery, Gunma University, Gunma, Japan.
Chikako SekineDepartment of Breast Surgery, International University of Health and Welfare, Chiba, Japan.
Mehra GolshanDivision of Surgical Oncology, Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
Emad A RakhaNottingham Breast Cancer Research Center, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham Biodiscovery Institute, University Park, Nottingham, UK.
Jun HoriguchiDepartment of Breast Surgery, International University of Health and Welfare, Chiba, Japan.
Sasagu KurozumiDepartment of Breast Surgery, International University of Health and Welfare, Chiba, Japan. skurozumi@iuhw.ac.jp.

Funding

Japan Society for the Promotion of Science 16K19906
6 · The paper itself

Abstract

introductionInvasive lobular carcinoma (ILC) is the second most common type of invasive breast cancer, following invasive breast cancer of no special type (IBC-NST). Due to the absence of cell adhesion factors, ILC is characterized by reduced cell adhesion and a linear or single-cell growth pattern. As a result, previous studies have frequently reported that ILC tends to spread more extensively than preoperative imaging evaluations suggest, often presents with multicentric lesions, and exhibits distinct recurrence and metastasis patterns compared with conventional invasive breast cancer.

methodsWe conducted a comprehensive literature search in PubMed, and performed a full-text screening for articles that met the inclusion criteria. Key information from each eligible study, including study design, population characteristics, primary outcomes, and conclusions were extracted.

resultsRecent translational research has identified several genes and molecular pathways associated with ILC progression and metastasis, with particular focus on the role of cancer-associated fibroblasts and the tumor microenvironment, including tumor-infiltrating immune cells.

conclusionWhile no specific treatment strategy for ILC has been established, its clinical, molecular, and morphological characteristics differ from those of IBC-NST, highlighting the need to develop targeted treatment approaches for ILC. This review examined the clinical, molecular, and morphological characteristics of ILC from a clinical perspective, incorporating recent findings from translational research.

Indexed as

Biomarkers, TumorBreast NeoplasmsCarcinoma, LobularTumor MicroenvironmentFemaleHumansNeoplasm InvasivenessPrognosisBiomarkers, TumorBreast cancerBreast oncologyInvasive breast cancer of no special type (IBC-NST)Invasive lobular carcinomaMolecular pathology

Identifiers

PMID40940597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.