ArticleAnnals of surgical oncology2026
Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery: A Large-Scale Exploratory Study.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The influence of preoperative bowel preparation on surgical site infection in pediatric colorectal surgery.Seminars in pediatric surgery · 2026Review
- Pre-operative habitual dietary fibre stratifies 12-week immune-inflammatory recovery after oesophagectomy: a multicentre prospective cohort study.Frontiers in nutrition · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundGut microbiota and intestinal environment are crucial in minimizing the risk for postoperative infectious complications of major gastrointestinal cancer surgery. However, comprehensive studies across multiple cancer types with large samples are limited. This study aimed to identify preoperative factors associated with the development of infectious complications after such surgeries.
methodsThis large-scale exploratory study examined 381 patients who underwent surgery for seven types of gastrointestinal cancer. Preoperative fecal samples were analyzed for fecal organic acid concentrations using high-performance liquid chromatography and gut microbiota composition 16S rRNA gene amplicon-sequencing. The relationships between specific gut bacteria, lactic acid concentrations, and postoperative infectious complications were analyzed.
resultsFecal lactic acid concentrations were significantly higher in patients who experienced postoperative infectious complications, indicating that lactic acid concentration is an independent risk factor. Greater preoperative abundances of Akkermansia muciniphila and Lactococcus lactis were associated with a lower incidence of postoperative infectious complications. Additionally, A. muciniphila abundance was positively correlated with preoperative blood neutrophil and lymphocyte counts.
conclusionsFecal lactic acid concentrations, A. muciniphila, and L. lactis were identified as factors associated with the development or suppression of postoperative infectious complications. These findings suggest novel avenues for predicting and managing infection risks through preoperative assessments and microbiota modulation.
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