Evidence map›Paper›PMID 40940577›Full record

ArticleMikrochimica acta2025

PNIPAAm-functionalized flexible microchip for rapid detection of surface microbial contaminants.

Xi Su, Chuang Ge, Songtao Xiang, Xiaoqin Wu, Yipei Wang, Li Chen, Yi Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xi SuSchool of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing, 314001, People's Republic of China.
Chuang GeKey Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, People's Republic of China.
Songtao XiangDepartment of Clinical Laboratory Medicine, Southwest Hospital, Army Medical University, Shapingba District, 30 Gaotanyan, Chongqing, 400038, People's Republic of China.
Xiaoqin WuKey Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba District, No. 174, St. Shazhengjie, Chongqing, 400044, People's Republic of China.
Yipei WangKey Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba District, No. 174, St. Shazhengjie, Chongqing, 400044, People's Republic of China.
Li ChenKey Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba District, No. 174, St. Shazhengjie, Chongqing, 400044, People's Republic of China.
Yi XuKey Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba District, No. 174, St. Shazhengjie, Chongqing, 400044, People's Republic of China. xuyibbd@cqu.edu.cn.

Funding

the National Key Research and Development Plan 2020YFB2009001the National Natural Science Foundation of China 62071072the Research start-up fund project of Jiaxing Nanhu University QD61220015the Science and Technology Planning Project of Jiaxing 2023AY11024
6 · The paper itself

Abstract

The detection of surface microbial contaminants faces several critical challenges, including disconnection between sampling and detection steps and time-consuming. To overcome these limitations, we developed an innovative integrated microfluidic system that combines bacterial sampling, transfer, concentration, and detection within a single chip platform. The microchip architecture consists of a thermos-responsive flexible sheet incorporating poly(N-isopropylacrylamide) (PNIPAAm) gel micropillar arrays for efficient bacterial capture and thermal-triggered release, and a PDMS cover layer with an optimized canopy-shaped microchannel design for sequential bacterial transport, fluorescent labeling, and in situ concentration/fluorescence detection. To verify the system's functionality, Staphylococcus aureus (S. aureus) was employed as a model organism for testing the microchip detection platform. Under optimized conditions, the sampling and the elution efficiency of S. aureus on stainless steel sheet were up to 75.6% and 88.4%, respectively. The detection limit of S. aureus was 5.15 × 10

Indexed as

Acrylic ResinsBacteriaEnvironmental MonitoringFomitesLab-On-A-Chip DevicesFluorescenceStaphylococcus aureusAcrylic Resinspoly-N-isopropylacrylamideBacterial detectionIntegrated biosensingMicrofluidic chipSurface-adhered bacteriaThermosensitive flexible sheet

Identifiers

PMID40940577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.