Evidence map›Paper›PMID 40940568›Full record

ArticleEMBO molecular medicine2025

Dietary supplementation of arachidonic acid promotes humoral immunity.

Shengyong Feng, Enhao Ma, Xiaona Na, Zongmei Wang, Wanbo Tai, Xinhui Bao, Mao Wang, Han Chang, Baolei Wu, Miaoxi Liu and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shengyong Feng *New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.
Enhao Ma *New Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.
Xiaona Na *Vanke School of Public Health, Tsinghua University, 100084, Beijing, China.
Zongmei Wang *National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Hubei Hongshan Laboratory, Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, 430070, Wuhan, China.
Wanbo TaiInstitute of Infectious Diseases, Shenzhen Bay Laboratory, 518000, Shenzhen, China.ORCID http://orcid.org/0000-0002-9864-8993
Xinhui BaoNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.
Mao WangNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.
Han ChangCollege of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.ORCID http://orcid.org/0009-0003-7816-0207
Baolei WuVanke School of Public Health, Tsinghua University, 100084, Beijing, China.
Miaoxi LiuDepartment of Microbiology & Immunology, University of California, San Francisco, CA, 94110, USA.ORCID http://orcid.org/0009-0000-2251-430X
Juzhen LiNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.
Huicheng ShiCollege of Food Science and Light Industry, Nanjing Tech University, 211816, Nanjing, China.
Celi YangVanke School of Public Health, Tsinghua University, 100084, Beijing, China.
Menglu XiVanke School of Public Health, Tsinghua University, 100084, Beijing, China.
Haibing YangVanke School of Public Health, Tsinghua University, 100084, Beijing, China.
Yuhan LiNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.
Yibin ZhuNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.
Penghua WangDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, 06030, USA.ORCID http://orcid.org/0000-0002-7332-1871
Ling ZhaoNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Hubei Hongshan Laboratory, Key Laboratory of Preventive Veterinary Medicine of Hubei Province, Huazhong Agricultural University, 430070, Wuhan, China. lingzhao@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0003-0569-8105
Ai ZhaoVanke School of Public Health, Tsinghua University, 100084, Beijing, China. aizhao18@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-1679-973X
Gong ChengNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China. gongcheng@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0001-7447-5488

Funding

Fundamental Research Fund for the Central Universities 2662025DKPY009MOST | National Natural Science Foundation of China (NSFC) 32188101MOST | National Natural Science Foundation of China (NSFC) 82271872MOST | National Natural Science Foundation of China (NSFC) 82341046Shenzhen Medical Research Fund B2404002Shenzhen San-Ming Project for Prevention and Research on Vector-borne Diseases SZSM202211023Yunnan Major Scientific and Technological Projects 202502AU100001Yunnan Provincial Science and Technology Project at Southwest United Graduate School 202302AO370010
6 · The paper itself

Abstract

Vaccination offers the most effective protection against contagious infectious diseases primarily by inducing humoral immunity. Vaccination efficacy is influenced by various factors. We report that dietary administration of arachidonic acid (ARA) significantly boosts rabies vaccine-induced production of neutralizing antibodies and protection against lethal rabies virus (RABV) infection in mice. In human volunteers, oral supplementation of ARA accelerates the expression of neutralizing antibodies to the levels sufficient for protection against RABV as early as one week after primary immunization. Mechanistically, ARA is enriched in lymph nodes and metabolized into immune modulators there. One of the ARA metabolites, prostaglandin I

Indexed as

Adjuvants, ImmunologicArachidonic AcidDietary SupplementsImmunity, HumoralRabiesRabies VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralB-LymphocytesFemaleHumansMaleMiceRabies virusAdjuvants, ImmunologicAntibodies, NeutralizingAntibodies, ViralArachidonic AcidRabies VaccinesArachidonic AcidGerminal Center ResponseHumoral Immunity

Identifiers

PMID40940568
PMCPMC12603062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.