Observational studyScientific reports2025
Influence of the SARS-CoV-2 pandemic and infection on musculoskeletal function.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03934957 (A Single Center, Prospective, Epidemiologic Cohort Study With Emphasis on Imaging to Improve the Identification of Individuals at Risk for Major Chronic Diseases and to Improve Early Diagnosis and Survival), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Single Center, Prospective, Epidemiologic Cohort Study With Emphasis on Imaging to Improve the Identification of Individuals at Risk for Major Chronic Diseases and to Improve Early Diagnosis and Survival
Who cites it
1 citing paper in PubMed.
- Ageing-related structural and cellular alterations in the mouse muscle-tendon junction.Biogerontology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As of September 2023, the number of SARS-CoV-2 infections worldwide has exceeded 770 million, with ongoing research recognizing its long-term health effects. This study investigates the effects of the pandemic on participants with and without SARS-CoV-2 infection on musculoskeletal status. The Hamburg City Health Study (HCHS) is an ongoing, prospective, population-based cohort study (trial registration number: NCT03934957). Participants (n = 2660) examined prior to the SARS-CoV-2 pandemic were compared with non-infected participants (n = 2660) in a 1:1 matched cohort analysis after the pandemic onset. Furthermore, participants who had recovered from a SARS-CoV-2 infection (n = 428) were compared with non-infected participants (n = 1712) in 1:4 matched cohort analysis. Increased relative fat mass and reduced skeletal muscle mass were observed in the post-pandemic group. No significant differences were observed between the groups regarding handgrip strength and timed up and go test. The comparison of the infection group with non-infected participants showed no significant differences in relative fat mass, handgrip strength and timed up and go test. The skeletal muscle mass was increased in the infection group but linear regression analysis adjusted for body surface area revealed no significant differences. This prospective study shows no association between SARS-CoV-2 infection and changes in basic musculoskeletal parameters in the cohort studied, suggesting that the infection may not be a significant cause of major deterioration in musculoskeletal function. Instead, it appears that lifestyle changes in daily routines and physical activities associated with the pandemic itself are the main influence on the musculoskeletal system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.