Evidence map›Paper›PMID 40940327›Full record

ArticleScientific reports2025

Impact of chewing muscle anesthesia on masticatory performance in healthy participants.

Dyanne Medina Flores, Tilda Karlsson, Giancarlo De La Torre Canales, Natalie Kaspo, Clara Malmström, Sara Messerer, Abhishek Kumar, Johanna Svedenlöf, Paulo Cesar Rodrigues Conti, Nikolaos Christidis and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dyanne Medina FloresDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden. dmedinafl@gmail.com.
Tilda KarlssonDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Giancarlo De La Torre CanalesDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Natalie KaspoDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Clara MalmströmDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Sara MessererDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Abhishek KumarDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Johanna SvedenlöfDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Paulo Cesar Rodrigues ContiDepartment of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (FOB/USP), Bauru, SP, Brazil.
Nikolaos ChristidisDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden.
Anastasios GrigoriadisDivision of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Huddinge, and Scandinavian Center for Orofacial Neurosciences, Huddinge, Sweden. anastasios.grigoriadis@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of the muscle spindles in the masticatory performance remains elucidated. This study aimed to investigate the impact of local anesthesia in the jaw-closing muscles on masticatory performance in healthy participants. Thirty healthy pain-free volunteers underwent in two rounds of chewing tasks involving two types of viscoelastic candies and a two-coloured chewing gum. Lidocaine (3.0 mL) was injected into a total of six points in the masseter and temporalis muscles bilaterally for the second round. Pain intensity, fatigue, the number and area of particles, and the degree of mixing of the chewing gum were assessed at baseline and after each round of chewing. The number of candy particles after injection of lidocaine, was significantly lower (33%) for women compared to the results without anesthesia (p < 0.05). There was no significant difference in the variance of hue of the two-coloured chewing-gum when comparing values before and after anesthesia. None of the participants experienced any pain during the experiment. However, self-reported fatigue increased during the second round, i.e., after anesthesia, with significantly higher values observed at the final assessment point. (p = 0.029). Local anesthesia of the jaw-closing muscles appears to impair the masticatory function in women, leading to reduced efficiency in food comminution compared to normal mastication. The observed sex differences suggest that women may be more vulnerable to neuromuscular control alterations following sensory alterations.

Indexed as

Anesthetics, LocalLidocaineMasseter MuscleMasticationAdultAnesthesia, LocalChewing GumFemaleHealthy VolunteersHumansMaleYoung AdultAnesthetics, LocalChewing GumLidocaineChewingFatigueMasticatory abilityMasticatory efficiency

Identifiers

PMID40940327
PMCPMC12432255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.