Evidence map›Paper›PMID 40940309›Full record

ArticleJournal of proteome research2025

Improving Proteomic Dynamic Range with Multiple Accumulation Precursor Mass Spectrometry.

Teeradon Phlairaharn, Ariana E Shannon, Xinlei Zeng, Dong-Jiunn Jeffery Truong, Erwin M Schoof, Zilu Ye, Brian C Searle

Abstract read
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Teeradon PhlairaharnDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota 55905, United States.
Ariana E ShannonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota 55905, United States.
Xinlei ZengState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Suzhou 215123, China.
Dong-Jiunn Jeffery TruongInstitute for Synthetic Biomedicine, Helmholtz Munich, Neuherberg 85764, Germany.
Erwin M SchoofDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby 2800, Denmark.ORCID 0000-0002-3117-7832
Zilu YeState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Suzhou 215123, China.
Brian C SearleDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota 55905, United States.ORCID 0000-0001-8760-6731

Funding

Investigating the functional impact of genetic variants in the human proteomeR35GM150723 · NIGMS · OHIO STATE UNIVERSITY · PI Brian Chih-Seng Searle · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM150723
6 · The paper itself

Abstract

Orbitrap (OT)-based mass spectrometer platforms are a gold standard in high-resolution mass spectrometry, where their primary disadvantage is slower-scanning speed in comparison to time-of-flight or linear ion trap mass analyzers. In this study, we utilize long OT transients to extend the precursor dynamic range by modifying the selected ion monitoring method to multiplex several precursor

Indexed as

Mass SpectrometryProteomicsTandem Mass SpectrometryHumansPeptidesSoftwarePeptidesdata-dependent acquisitiondata-independent acquisitionmass spectrometrymultiplexingorbitrap mass analyzerpeptide identification optimizationpeptide quantification optimization

Identifiers

PMID40940309
PMCPMC13312262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.