Evidence map›Paper›PMID 40940173›Full record

ArticleSeminars in oncology nursing2025

Poorer Quality of Life Outcomes Are Associated with Higher Levels of Stress, Lower Levels of Resilience, and Poorer Adjustment to Cancer in Outpatients Receiving Chemotherapy.

Jung Ae Kim, Astrid Block, Sueann Mark, Bruce A Cooper, Steven M Paul, Frances Cartwright, Marilyn J Hammer, Yvette P Conley, Jon D Levine, Christine Miaskowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in oncology nursing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jung Ae KimSchool of Nursing, University of California, San Francisco, California, USA.
Astrid BlockSchool of Nursing, University of California, San Francisco, California, USA.
Sueann MarkSchool of Nursing, University of California, San Francisco, California, USA.
Bruce A CooperSchool of Nursing, University of California, San Francisco, California, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, California, USA.
Frances CartwrightMount Sinai Medical Center, New York, New York, USA.
Marilyn J HammerPhyllis F. Cantor Center, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, California, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, California, USA; School of Medicine, University of California, San Francisco, California, USA. Electronic address: chris.miaskowski@ucsf.edu.

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
NCI NIH HHS R01 CA134900
6 · The paper itself

Abstract

objectivesThe purposes were to identify subgroups of patients (n = 1324) with distinct quality of life (QOL) profiles and evaluate for differences among these subgroups in demographic and clinical characteristics, as well as levels of global, cancer-related, and cumulative life stress; resilience; and mental adjustment to cancer.

methodsPrior to their second or third cycle of chemotherapy, patients completed a demographic questionnaire, measures of stress (Perceived Stress Scale, global stress), Impact of Event Scale-Revised (IES-R, cancer-related distress), Life Stressor Checklist-Revised (LSC-R, cumulative life stress); resilience (Connor-Davidson Resilience Scale [CDRS]), and mental adjustment (Mental Adjustment to Cancer Scale [MAC]). In addition, they completed the Multidimensional QOL Scale-Patient Version six times over two cycles of chemotherapy. Latent profile analysis was used to identify the distinct QOL profiles. Parametric and nonparametric tests were used to evaluate for differences in risk factors among the QOL profiles.

resultsThree distinct QOL profiles were identified (Low, 26.9%; Moderate, 44.7%; and High, 28.4%). Compared to the High QOL class, the other two classes were younger and more likely to be female and had a higher comorbidity burden and lower functional status. Differences among the QOL classes in PSS, IES-R, and LSC-R scores followed a similar pattern (Low > Moderate > High). Differences were found among the QOL classes in CDRS (Low < Moderate < High) and MAC (Low > Moderate > High) scores.

conclusionsThis study is the first to describe interindividual variability in QOL outcomes among patients receiving chemotherapy. Levels of cancer-related stress reported by Low and Moderate QOL classes suggest that these patients meet the diagnostic criteria for posttraumatic stress and have levels of resilience below the normative score for the general population. IMPLICATIONS FOR NURSING PRACTICE: Given that stress and resilience are modifiable risk factors, this information can be used by clinicians to design tailored interventions to improve patients' QOL.

Indexed as

Adaptation, PsychologicalAntineoplastic AgentsNeoplasmsOutpatientsQuality of LifeResilience, PsychologicalStress, PsychologicalAdultAgedFemaleHumansMaleMiddle AgedSurveys and QuestionnairesAntineoplastic AgentsCancerChemotherapyComorbidityDepressionLatent profile analysisMental adjustment to cancerPatient-reported outcomesPosttraumatic stress disorderQuality of lifeResilienceStress

Identifiers

PMID40940173
PMCPMC13235281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.