ArticleJACC. Case reports2025
5-Fluorouracil-Induced Microvascular Vasospasm Diagnosed by Coronary Functional Testing.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effective management of 5-fluorouracil-induced coronary vasospasm allowing chemotherapy continuation: a single-center observational study.Cardio-oncology (London, England) · 2026Article
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5 authors.
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Abstract
backgroundThe 5-fluorouracil (5-FU) component of 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy is a known cause of coronary vasospasm. Diagnosis can be difficult, often leading to interruption of chemotherapy. CASE SUMMARY: A 53-year-old man with a history of colorectal cancer developed new-onset angina after initiation of FOLFOX chemotherapy. He underwent a left heart catheterization, coronary functional testing (CFT), and acetylcholine (ACh) provocation. ACh provocation elicited similar angina, consistent with microvascular vasospasm. This prompted initiation of calcium-channel blockers and adjustments to chemotherapy administration, preventing further angina. DISCUSSION: CFT with ACh provocation should be considered in patients undergoing chemotherapy with 5-FU. As 5-FU coronary vasospasm is often transient, ACh provocation can identify patients who would benefit from calcium-channel blockers and changing 5-FU administration from continuous to bolus dosing. TAKE-HOME MESSAGE: This case highlights the utility of CFT in identifying and guiding treatment in suspected cases of 5-FU-associated coronary vasospasm.
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