Evidence map›Paper›PMID 40940081›Full record

Trial reportBMJ (Clinical research ed.)2025

Effectiveness of YCMAP (youth culturally adapted manual assisted problem solving) intervention in adolescents after self-harm in Pakistan: multicentre, randomised controlled trial.

Nusrat Husain, Sehrish Tofique, Tayyeba Kiran, Matthias Pierce, Imran B Chaudhry, M Omair Husain, Rakhshi Memon, Ahmed Waqas, Nadeem Gire, Sarah Edwards and 17 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in BMJ (Clinical research ed.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04131179 (Youth Culturally Adapted Manual Assisted Psychological Therapy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04131179 nacompletednot on this map

Youth Culturally Adapted Manual Assisted Psychological Therapy (Y-CMAP) in Adolescents Pakistani Patients With a History of Self Harm

TypeinterventionalSponsorPakistan Institute of Living and LearningRan2019 to 2023Enrolled684ConditionsSelf HarmArmsYouth Culturally Adapted Manual Assisted Psychological Therapy (Y-CMAP)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Nusrat HusainDivision of Psychology and Mental Health, The University of Manchester School of Health Sciences, Manchester, UK.ORCID 0000-0002-9493-0721
Sehrish TofiqueDivision of Neuro-Cognitive Disorder, Older Adults Mental Health, Pakistan Institute of Living and Learning, Karachi, Pakistan.ORCID 0000-0002-8027-054X
Tayyeba KiranDivision of Mood Disorder, Pakistan Institute of Living and Learning, Karachi, Pakistan.ORCID 0000-0003-2478-4148
Matthias PierceDivision of Psychology and Mental Health, The University of Manchester School of Health Sciences, Manchester, UK.ORCID 0000-0003-2182-0369
Imran B ChaudhryDivision of Psychology and Mental Health, The University of Manchester School of Health Sciences, Manchester, UK.ORCID 0000-0003-4028-1831
M Omair HusainCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0002-8575-3364
Rakhshi MemonScience and Technology Studies, University College London, London, UK.ORCID 0000-0002-6586-2248
Ahmed WaqasFaculty of Health and Life Sciences, University of Liverpool, Liverpool UK.ORCID 0000-0002-3772-194X
Nadeem GireDivision of Psychology and Mental Health, The University of Manchester School of Health Sciences, Manchester, UK.ORCID 0000-0002-4130-6626
Sarah EdwardsScience and Technology Studies, University College London, London, UK.ORCID 0000-0002-1723-5012
Paul BassittStatsconsultancy, Amersham, UK.
Suleman ShakoorDivision of Biostatistics, Pakistan Institute of Living and Learning, Karachi, Pakistan.ORCID 0000-0003-1903-4844
Zainab F ZaddehDivision of Child and Adolescents, Pakistan Institute of Living and Learning, Karachi, Pakistan.ORCID 0000-0001-7671-8885
Usman ArshadDepartment of Evidence Synthesis, Pakistan Institute of Living and Learning, Karachi, Pakistan.ORCID 0000-0002-2096-8014
Erminia ColucciDepartment of Psychology, Middlesex University, London, UK.
Faraz MughalDepartment of General Practice and Primary Care, Melbourne Medical School, University of Melbourne, Australia.ORCID 0000-0002-5437-5962
Samia ShahidDivision of Mood Disorder, Pakistan Institute of Living and Learning, Karachi, Pakistan.
Maria PanagiotiDivision of Population Health, Health Services Research & Primary Care, Manchester, UK.ORCID 0000-0002-7153-5745
Asad T NizamiInstitute of Psychiatry, Punjab, Pakistan.
Farhat JafriCommunity Medicine, Karachi Medical and Dental College, Karachi, Pakistan.ORCID 0000-0003-2466-7283
Farooq NaeemDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4760-4840
Richard EmsleyDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-1218-675X
Moin A AnsariDepartment of Psychiatry, Sir Cowasjee Jehangir Institute, Hyderabad, Pakistan.
Sarwat SultanDepartment of Applied Psychology, Bahauddin Zakariya University, Multan, Pakistan.
Shilpa AggarwalIMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.ORCID 0000-0002-8590-0846
Christopher WilliamsSchool of Health & Wellbeing, University of Glasgow, Glasgow, UK.
Nasim ChaudhryPakistan Institute of Living and Learning, Karachi, Pakistan.ORCID 0000-0003-4142-868X

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectiveTo evaluate the clinical effectiveness of the YCMAP intervention (Youth Culturally Adapted Manual Assisted Problem Solving) for adolescents after self-harm in Pakistan.

designMulticentre, randomised controlled trial that compared YCMAP with enhanced treatment as usual. SETTINGS: General practices, emergency departments, medical wards of participating hospitals, and community centres across Karachi, Hyderabad, Lahore, Multan, and Rawalpindi.

participantsAdolescents with a recent history of self-harm identified at participating health centres by treating physicians between 5 November 2019 and 31 August 2021.

interventionThe YCMAP group received up to 10 treatment sessions over three months; the intervention was based on the principles of cognitive behaviour therapy.

main outcome measureThe primary outcome was the repetition of self-harm at 12 months after randomisation. Secondary outcomes were distress, hopelessness, suicidal ideation, and health related quality of life at three, six, nine, and 12 months after randomisation. Participants' satisfaction with the services was assessed at three and 12 months after randomisation.

resultsThis trial was conducted between November 2019 and February 2023 and included 684 adolescents randomised to YCMAP (n=342) or enhanced treatment as usual (n=342). The YCMAP group had a significantly lower risk of self-harm repetition than the enhanced treatment as usual group at 12 months after randomisation (odds ratio 0.20, 95% confidence interval 0.06 to 0.70, P=0.006). YCMAP participants showed a statistically significant reduction in distress, hopelessness, and suicidal ideation at three months, but these differences were not statistically significant at 12 months. YCMAP participants also reported significantly better quality of life and satisfaction with services at three months, with these effects sustained at all follow-up points.

conclusionThe YCMAP intervention was shown to be beneficial in self-harm prevention among adolescents. Further research and replication of findings in diverse settings are recommended to strengthen the evidence base for this public health intervention.

trial registrationClinicalTrials.gov NCT04131179 and ISRCTN registry ISRCTN57325925.

Indexed as

Cognitive Behavioral TherapyProblem SolvingSelf-Injurious BehaviorAdolescentFemaleHumansMalePakistanQuality of LifeSuicidal IdeationTreatment Outcome

Identifiers

PMID40940081
PMCPMC12426884

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.