Evidence map›Paper›PMID 40940055›Full record

ArticleBMJ open2025

Randomised controlled trial to measure effectiveness and cost-effectiveness of a digital social intervention promoted by primary care clinicians to adults with asthma to improve asthma control: protocol.

Georgios Dimitrios Karampatakis, Helen E Wood, Chris J Griffiths, Stephanie Jc Taylor, Veronica Toffolutti, Victoria J Bird, Nathan C Lea, Richard Ashcroft, Neil S Coulson, Pietro Panzarasa and 11 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06849245 (Measuring Whether Promotion of a Digital Social Intervention by Primary Care Healthcare Professionals and Subsequent Engagement With Online Peer Support Improves Health and Well-being of Patients With Asthma and is Cost-effective), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06849245 narecruitingnot on this map

Measuring Whether Promotion of a Digital Social Intervention by Primary Care Healthcare Professionals and Subsequent Engagement With Online Peer Support Improves Health and Well-being of Patients With Asthma and is Cost-effective: a Randomised Controlled Trial

TypeinterventionalSponsorQueen Mary University of LondonRan2025 to 2027Enrolled600ConditionsAsthma Intermittent, UncontrolledArmsA digital social intervention by primary care clinicians
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Georgios Dimitrios KarampatakisCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK g.karampatakis@qmul.ac.uk.ORCID http://orcid.org/0000-0003-0623-8231
Helen E WoodCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0009-0008-6940-6427
Chris J GriffithsCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-7935-8694
Stephanie Jc TaylorCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-7454-6354
Veronica ToffoluttiCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Victoria J BirdCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-2053-7679
Nathan C LeaDepartment of Medical Informatics & Statistics, The European Institute for Innovation through Health Data, Ghent University Hospital, Ghent, Belgium.
Richard AshcroftThe City Law School, City St George's, University of London, London, UK.
Neil S CoulsonSchool of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0001-9940-909X
Pietro PanzarasaSchool of Business and Management, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-7596-4806
Xiancheng LiSchool of Business and Management, Queen Mary University of London, London, UK.
Aziz SheikhCentre for Applied Respiratory Research, Innovation and Impact, Queen Mary University of London, London, UK.
Clare ReltonCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-8530-5011
Nishanth SastrySurrey Centre for Cyber Security, Department of Computer Science, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-4053-0386
Jane S WatsonRespiratory Department, St George's Healthcare NHS Trust, London, UK.
Jonathan MantDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9531-0268
Viv MarshCentre for Applied Respiratory Research, Innovation and Impact, Queen Mary University of London, London, UK.
Bill DayCentre for Applied Respiratory Research, Innovation and Impact, Queen Mary University of London, London, UK.ORCID http://orcid.org/0009-0004-6894-7716
Borislava MihaylovaCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-0951-1304
Neil WalkerCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Anna De SimoniCentre for Primary Care, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-6955-0885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn the UK, approximately 5.4 million adults live with asthma, of whom one in five have an uncontrolled form. Uncontrolled asthma reduces quality of life and increases healthcare use. Engaging with peers through online health communities (OHCs) can empower patients to self-manage their long-term condition. While OHCs have been in existence for several years and growing numbers of patients access them, the role of primary care in signposting patients to them has been minimal and ad hoc. We have co-developed with patients and healthcare professionals (HCPs) an intervention for adult patients with asthma, consisting of an appointment with a primary care HCP to introduce online peer support and sign patients up to an established asthma OHC, followed by OHC engagement. Feasibility work found the intervention acceptable to patients and HCPs. This protocol outlines our plan to test the intervention's effectiveness and cost-effectiveness. METHODS AND ANALYSIS: An individual randomised controlled trial will be carried out. Eligible participants will be recruited via an online survey sent to adult patients on the asthma register in 50-70 general practices in several UK locations. Participants will be invited to attend a one-off, face-to-face appointment with a primary care HCP, during which they will be individually randomised to the intervention or usual care. An asthma control test (primary outcome) and other measures of clinical effectiveness will be collected at baseline and every 3 months over a 12-month follow-up period. Descriptive and inferential statistics will be used to compare outcome measures between study arms. Cost-effectiveness assessment of the intervention compared with current standard of asthma management in primary care will be reported. A sample of patients and HCPs will be interviewed at study exit and the data analysed thematically. ETHICS AND DISSEMINATION: The study was approved by a National Health Service Research Ethics Committee (reference: 25/NE/0006). Written consent will be obtained from all participants. Findings will be disseminated through various means, including sharing with general practices, conference presentations and peer-reviewed publications. TRIAL REGISTRATION NUMBER: NCT06849245.

Indexed as

AsthmaPrimary Health CareSocial SupportAdultCost-Benefit AnalysisFemaleHumansMalePeer GroupQuality of LifeRandomized Controlled Trials as TopicUnited Kingdomasthmaprimary careprotocols & guidelinesrandomized controlled trialself caresocial media

Identifiers

PMID40940055
PMCPMC12434742

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.