ArticleBMJ open2025
Study protocol for healthy hearts: a prospective observational cohort study on dyadic management of HIV and cardiometabolic comorbidities in couples from Malawi.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Cross-Lagged Dyadic Associations of Food Insecurity and Depressive Symptoms among Couples Living with HIV and Cardiometabolic Disorders in Malawi.Current developments in nutrition · 2026Article
- Couples problem-solving therapy for perinatal women living with HIV and male partners in Malawi: a study protocol for a pilot trial ofBMJ open · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionAs the HIV epidemic stabilises in Sub-Saharan Africa with effective antiretroviral therapy, cardiometabolic disorders (CMDs) remain the next major challenge for people living with HIV. Relationship dynamics and spousal support are important for the medical management of single diseases such as HIV, yet little is known about how couples manage the complexity of multiple competing health conditions and their synergistic effects on health. The METHODS AND ANALYSIS: This study will enrol 250 couples who have at least one partner living with HIV and CMD (either hypertension or diabetes) for a prospective observational cohort study. Patients will be recruited from HIV and CMD clinics in Zomba and Blantyre, Malawi. Couples will attend four study visits at quarterly intervals over 12 months. Both partners are given interviewer-administered surveys and complete a clinical assessment. Regression techniques will be used to test associations between key constructs in our conceptual model, including communal coping, multimorbidity illness perceptions, relationship quality, psychosocial health, disease management (eg, adherence to lifestyle advice and medications) and disease outcomes (eg, viral suppression and CMD control). Findings will be used to identify elements to target in a couple-based intervention for CMD and HIV. ETHICS AND DISSEMINATION: This study was approved by the University of California, San Francisco (HRPP (Human Research Protection Program); Protocol number 20-32126), and the National Health Sciences Research Committee of Malawi (Protocol number 21/04/2677). The results will be disseminated at local community meetings and conferences focused on relationships, CMDs and HIV and published in scientific journals.
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