Evidence map›Paper›PMID 40940010›Full record

ArticleJournal of natural products2025

Structure Determination and Biosynthesis of Dapalides A-C, Glycosylated Kahalalide F Analogues from the Marine Cyanobacterium

Emma K Ellis, Laura P Ióca, Jie Liu, Manyun Chen, Steven D Bruner, Yousong Ding, Valerie J Paul, Mohamed S Donia, Hendrik Luesch

Erratum issuedAbstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Biosynthetic origin of anticancer dolastatin 15 reveals a noncanonical NRPS architecture enabling 2-keto acid activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Emma K EllisDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.
Laura P IócaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-9288-6405
Jie LiuDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
Manyun ChenDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID 0000-0001-6803-044X
Steven D BrunerCenter for Natural Products, Drug Discovery, and Development, University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID 0000-0002-0522-480X
Yousong DingDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID 0000-0001-8610-0659
Valerie J PaulSmithsonian Marine Station, 701 Seaway Drive, Fort Pierce, Florida 34949, United States.ORCID 0000-0002-4691-1569
Mohamed S DoniaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
Hendrik LueschDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID 0000-0002-4091-7492

Funding

Integrative Multidisciplinary Discovery Platform to Unlock Marine Natural Products Therapeutic OpportunitiesRM1GM145426 · NIGMS · UNIVERSITY OF FLORIDA · PI Mohamed Abou Donia, Steven D Bruner · 2022 to 2026
$8.8M
NIH Equipment Supplement to R35GM128742R35GM128742 · NIGMS · UNIVERSITY OF FLORIDA · PI Yousong Ding · 2018 to 2026
$3.4M
Chemistry-Biology Interface Training Program at the University of FloridaT32GM136583 · NIGMS · UNIVERSITY OF FLORIDA · PI Chenglong Li · 2020 to 2026
$1.1M
NMR console upgrade for structural biology and metabolomicsS10OD028753 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2020 to 2020
$600k
NIGMS NIH HHS R35 GM128742NIGMS NIH HHS RM1 GM145426NIGMS NIH HHS T32 GM136583NIH HHS S10 OD028753
6 · The paper itself

Abstract

Kahalalides were originally isolated from the marine mollusk

Indexed as

CyanobacteriaDepsipeptidesAnimalsAntineoplastic AgentsGlycosylationHumansMarine BiologyMolecular StructureMultigene FamilyAntineoplastic AgentsDepsipeptides

Identifiers

PMID40940010
PMCPMC12481561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.