Evidence map›Paper›PMID 40939997›Full record

ArticleJournal of affective disorders2026

Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima.

Ana L Vilela-Estrada, Maria Lazo-Porras, Antonio Bernabe-Ortiz, Stefan Priebe, Victoria J Bird, Karen Ariza-Salazar, Diliniya Stanislaus Sureshkumar, Natalia Godoy-Casasbuenas, Carlos Gómez-Restrepo, Natividad Olivar and 3 more

Abstract read
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ana L Vilela-EstradaCRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru. Electronic address: ana.vilela.e@upch.pe.
Maria Lazo-PorrasCRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Antonio Bernabe-OrtizCRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Stefan PriebeUnit for Social and Community Psychiatry, East London NHS Foundation Trust, London, United Kingdom.
Victoria J BirdUnit for Social and Community Psychiatry, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
Karen Ariza-SalazarDepartment of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia.
Diliniya Stanislaus SureshkumarUnit for Social and Community Psychiatry, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
Natalia Godoy-CasasbuenasDepartment of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia.
Carlos Gómez-RestrepoDepartment of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia; Department of Psychiatry and Mental Health, Pontificia Universidad Javeriana, Bogotá, Colombia; Hospital Universitario San Ignacio, Bogotá, Colombia.
Natividad OlivarDepartment of Psychiatry and Mental, School of Medicine, University of Buenos Aires, Argentina.
Sofia MaderoDepartment of Psychiatry and Mental, School of Medicine, University of Buenos Aires, Argentina.
Luis Ignacio BruscoDepartment of Psychiatry and Mental, School of Medicine, University of Buenos Aires, Argentina.
Francisco Diez-CansecoCRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to (1) examine the association between comorbid anxiety and depressive symptoms and quality of life (QoL) among adolescents and young adults and assess whether perceived social support modifies this relationship; and (2) explore the association between comorbid symptoms and use of mental health (MH) services, considering QoL as a potential effect modifier.

methodsA cross-sectional study was conducted with 1816 adolescents and young adults aged 15-24 years from socioeconomically disadvantaged urban areas of Bogotá, Buenos Aires, and Lima. The analysis included descriptive statistics, bivariate tests, and multivariable generalised linear models to assess associations with QoL. Poisson regression models were used to examine the association with MH service use. Interaction terms were included to assess potential effect modification by social support and QoL, with all models adjusted for relevant sociodemographic and contextual confounders.

resultsComorbidity of depressive and anxiety symptoms was associated with lower QoL scores (β = -0.71; p < 0.001). Higher perceived social support was positively associated with QoL and significantly moderated the comorbidity and QoL relationship (p < 0.001). Additionally, comorbidity was linked to increased use of MH services (PR = 1.98; p < 0.001). Each QoL additional point was associated with a reduction of 25 % in MH service use (p < 0.001); but QoL did not modify the association between comorbidity and service use, despite being close to significance (p = 0.063). DISCUSSION: Addressing both emotional symptoms and social factors is essential for improving youth well-being. Findings support strengthening social support networks and expanding access to services for vulnerable groups.

Indexed as

AnxietyAnxiety DisordersDepressionMental Health ServicesQuality of LifeSocial SupportAdolescentArgentinaComorbidityCross-Sectional StudiesFemaleHumansMaleYoung AdultAnxietyComorbidityDepressionQuality of lifeSocial support and mental health services

Identifiers

PMID40939997
PMCPMC12598458

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.