Evidence map›Paper›PMID 40939936›Full record

ArticleChest2026

Identifying Critical Windows and Joint Effects of Prenatal Air Pollution and Temperature Exposure and Lung Function in Schoolchildren: Findings From a Prospective Birth Cohort Study.

Cheng-Yang Hu, Cecilia Sara Alcala, Hector Lamadrid-Figueroa, Adriana Mercado-Garcia, Marcela Tamayo-Ortiz, Ivan Gutierrez-Avila, Itai Kloog, Allan C Just, Mike Z He, Maayan Yitshak-Sade and 6 more

Abstract read
In one paragraph

Article in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Prenatal PMRespirology (Carlton, Vic.) · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Cheng-Yang HuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Cecilia Sara AlcalaDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Hector Lamadrid-FigueroaDepartment of Perinatal Health, Center for Population Health Research, National Institute of Public Health (INSP), Cuernavaca, Mexico.
Adriana Mercado-GarciaCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Marcela Tamayo-OrtizDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY.
Ivan Gutierrez-AvilaDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Itai KloogDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Allan C JustDepartment of Epidemiology, School of Public Health, Brown University, Providence, RI.
Mike Z HeDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Maayan Yitshak-SadeDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Nadya Y Rivera-RiveraDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Guadalupe Estrada-GutierrezDepartment of Immunobiochemistry, National Institute of Perinatology, Mexico City, Mexico.
Martha M Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Robert O WrightDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY.
Rosalind J WrightDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY.
Maria José RosaDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: maria.rosa@mssm.edu.

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
Effect of Perinatal Exposure to Metals on Lung Function Trajectories and Mitochondrial DNA Heteroplasmy from Childhood to AdolescenceR01ES033245 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2022 to 2026
$3.0M
Ambient Air Pollution, Stress, Oxidative Markers and Respiratory Health in Mexican ChildrenR00ES027496 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROSA, MARIA JOSE · 2019 to 2021
$743k
The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) CohortU24ES028522 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HORTON, MEGAN K, ROSA, MARIA JOSE · 2024 to 2025
$719k
A Community Partnered Approach to Assessing the Impact of Prenatal Pesticide Exposure on Child Respiratory Outcomes in Mexico CityK99ES035894 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALCALA, CECILIA SARA · 2024 to 2024
$106k
NCATS NIH HHS UL1 TR004419NIEHS NIH HHS K99 ES035894NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES027496NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R01 ES033245NIEHS NIH HHS U24 ES028522
6 · The paper itself

Abstract

backgroundAir pollution and extreme temperature exposure during pregnancy is associated with lung function in schoolchildren. RESEARCH QUESTION: What are the critical time windows during pregnancy when exposure to air pollution (fine particulate matter [PM STUDY DESIGN AND

methodsWithin the Programming Research in Obesity, Growth, Environment, and Social Stressors study, daily residential levels of pollutant/temperature exposures during pregnancy were generated from satellite-based models. Lung function was evaluated at ages 8 to 14 years and was modeled as z scores adjusted for age, height, and sex. We used distributed lag nonlinear models to evaluate overall and sex-specific associations of exposures with lung function outcomes. Interactive effects were evaluated through the relative excess risk due to interaction and the attributable proportion.

resultsA total of 429 mother-child dyads were included. Prenatal higher PM

interpretationOur findings emphasize detrimental effects of early-life air pollution exposure on long-term respiratory health and suggest potential sex-specific vulnerabilities, informing targeted interventions to protect child health.

Indexed as

Air PollutionLungPrenatal Exposure Delayed EffectsAdolescentBirth CohortChildFemaleForced Expiratory VolumeHumansMaleNitrogen DioxideParticulate MatterPregnancyProspective StudiesRespiratory Function TestsTemperatureNitrogen DioxideParticulate Matterextreme temperatureslung functionNO(2)PM(2.5)

Identifiers

PMID40939936
PMCPMC12809656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.