Trial reportChest2026
Effectiveness of Health Communication Intervention to Improve Knowledge on Timeliness to Return for Annual Lung Cancer Screening: The Larch Trial.
Trial report in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05747443 (Multilevel Interventions to Increase Adherence to Lung Cancer Screening), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multilevel Interventions to Increase Adherence to Lung Cancer Screening
Who cites it
2 citing papers in PubMed.
- Health Communication and Stepped Reminders Interventions for Lung Cancer Screening: A Randomized Clinical Trial.JAMA internal medicine · 2026Trial
- Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundMany patients are unaware of the need to repeat lung cancer screening (LCS) annually despite shared decision-making. A health communication intervention was tested to improve patient knowledge, tobacco-related stigma, and self-efficacy in LCS. RESEARCH QUESTION: Does additional health communication improve patient knowledge of LCS timeliness? STUDY DESIGN AND
methodsTrial participants aged 50 to 78 years with a normal LCS scan were randomized to the intervention or control arm. The intervention was delivered 3 weeks following an LCS scan. Intervention participants received health communication (print plus video) with 3 key messages to normalize routine LCS; a reminder of when due for screening; and encouraging social connection. Interventions were primarily delivered through the electronic health record patient portal. Eight weeks following the scan, all participants were invited to complete an online or telephone survey about knowledge, tobacco-related stigma, and self-efficacy. Modified Poisson and linear regression was used to test association of the intervention on secondary trial outcomes, using weights to account for survey nonresponse. Heterogeneity of the intervention effect was tested by using tobacco and LCS histories.
resultsThe survey participation rate was 38.9% with 714 respondents (n = 363 intervention; n = 351 control). Knowledge to return in 1 year improved by 13% in the intervention arm vs the control arm (relative risk, 1.13; 95% CI, 1.05-1.22; P < .001). Intervention increased the proportion by 21.9% who knew to return in 1 year from 62.0% to 83.9% (relative risk, 1.35; 95% CI, 1.16-1.58) in first-time screeners but no difference in those screened 2 or more times. No other statistically significant differences in knowledge were detected. In the control arm, both tobacco-related stigma (mean, 13.9; 95% CI, 13.6-14.2) and self-efficacy (mean, 29.0; 95% CI, 28.6-29.4) were high and unchanged by the intervention.
interpretationA multiformat LCS intervention was shown to improve short-term knowledge of LCS timeliness to return. This finding suggests that additional health communication beyond shared decision-making might encourage repeat screening, especially in first-time screeners. CLINICAL
trial registrationClinicalTrials.gov; No.: NCT05747443; URL: www. CLINICALTRIALS: gov.
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