Evidence map›Paper›PMID 40939773›Full record

ArticleExperimental gerontology2025

Chronic pain and subjective memory problems are dynamic risk factors for functional decline: An ACTIVE longitudinal study.

Tyler R Bell, Cynthia Felix, Nathalie Gider, George W Rebok, Michael Crowe, Karlene Ball, Gail Wallace, Sheila Black, Kelsey R Thomas, Katie M Wheeler and 3 more

Abstract read
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In one paragraph

Article in Experimental gerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tyler R BellDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA. Electronic address: trbell@health.ucsd.edu.
Cynthia FelixDepartment of Psychiatry, University of Pittsburgh, PA, USA.
Nathalie GiderDepartment of Cognitive Science, University of California San Diego, La Jolla, CA, USA.
George W RebokDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, MD, USA.
Michael CroweDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Karlene BallDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Gail WallaceDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, MD, USA.
Sheila BlackDepartment of Psychology, University of Alabama, Tuscaloosa, AL, USA.
Kelsey R ThomasDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA.
Katie M WheelerDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Felix J KollasserrySchool of Computing and Information, University of Pittsburgh, PA, USA.
Jeanine M ParisiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, MD, USA.
Caitlin A NorthcuttDepartment of Epidemiology & Environmental Health, Kentucky Injury Prevention and Research Center, University of Kentucky, Lexington, KY, USA.

Funding

Chronic Pain and Risk of Alzheimer's-Related NeurodegenerationK01AG081559 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tyler Reed Bell · 2023 to 2026
$505k
NIA NIH HHS K01 AG081559
6 · The paper itself

Abstract

Chronic pain is highly prevalent in older adults and is associated with elevated risk for disability and dementia. Subjective memory problems (SMPs) - self-rated memory difficulties - are also common and may serve as early indicators of functional decline. This study examined associations between SMPs and cognitive, physical, and psychosocial functioning among older adults with and without chronic pain. Data were drawn from 2365 participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study. Multilevel models assessed the impact of baseline and time-varying SMPs on cognitive performance (memory, reasoning, processing speed), physical function (mobility, grip strength, self-rated physical health), and psychosocial outcomes (depressive symptoms, social functioning). Chronic pain, defined as moderate-to-severe pain using the SF-36 Bodily Pain Scale, was tested as a moderator. At baseline, greater SMPs were associated with poorer cognitive performance (βs: -0.52 to -0.23). SMPs and chronic pain were independently linked to worse physical function, lower social functioning, and more depressive symptoms (βs: -0.94 to -0.34; 0.51 to 1.01). Chronic pain uniquely predicted worse mobility and reduced grip strength. Prospectively, SMPs interacted with chronic pain to predict steeper declines in reasoning and physical function. Concurrent increases in SMPs paralleled further declines in most cognitive, physical, and psychosocial domains. Findings suggest that SMPs are stronger predictors of certain outcomes among older adults with chronic pain. These results highlight the importance of jointly considering subjective memory problems and chronic pain to better identify individuals at heightened risk for accelerated functional decline in later life.

Indexed as

Chronic PainMemory DisordersAgedAged, 80 and overCognitionDepressionFemaleHand StrengthHumansLongitudinal StudiesMaleRisk FactorsChronic painCognitive functionPhysical functionSocial functionSubjective memory

Identifiers

PMID40939773
PMCPMC13283466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.