ArticleJournal of the American Chemical Society2025
pH-Responsive Self-Assembly of Renal-Clearable Nanoparticles in the Kidneys: One Assembly per Endosome.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Application-Driven Modular Design of Gold Nanoclusters for In Vivo Fluorescence Imaging.Small methods · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Renal clearance is traditionally viewed as a passive filtration process governed by fenestrated glomerular capillaries. However, proximal tubular epithelial cells (PTECs) can still actively internalize, transform, and re-eliminate nanoparticles following glomerular filtration. Herein, we report that pH-responsive renal-clearable gold nanoparticles (AuNPs) of ∼2 nm in size can rapidly self-assemble into a single ∼180 nm nanosphere within individual PTEC endosomes in vivo once their isoelectric points (IEPs) overlapping the endocytic pH range (4.5-6.5), which has never been observed at the animal level. This pH-triggered one assembly per endosome delays subsequent reactive oxygen species (ROS)-mediated intracellular biotransformation into larger nanostructures while preserving membrane extrusion-based re-elimination. These findings reveal that endosomal acidity, alongside ROS, is a critical determinant of nanoparticle biotransformation and suggest that tailoring isoelectric points offers a route to control the subcellular assembly and clearance of renal-clearable nanomedicines at the animal level.
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Registered trials
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