Evidence map›Paper›PMID 40939165›Full record

ArticleACS chemical neuroscience2025

Antidepressant-like Properties of a Selenium-Containing Pyridinium Salt Explored through In Vitro, In Vivo, and In Silico Approaches.

Mariana Parron Paim, Taís da Silva Teixeira Rech, Letícia Devantier Krüger, Larissa Sander Magalhães, Filipe Penteado, Caroline Signorini Gomes, Eder João Lenardão, César Augusto Brüning, Cristiani Folharini Bortolatto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariana Parron PaimPostgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Taís da Silva Teixeira RechPostgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Letícia Devantier KrügerPostgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Larissa Sander MagalhãesPostgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Filipe PenteadoCenter for Natural and Exact Sciences-CCNE, Federal University of Santa Maria-UFSM, Roraima Avenue, Building 18, 97105-340 Santa Maria, Rio Grande do Sul, Brazil.
Caroline Signorini GomesPostgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Eder João LenardãoPostgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.
César Augusto BrüningPostgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.ORCID 0000-0003-0814-0203
Cristiani Folharini BortolattoPostgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.ORCID 0000-0002-9509-4446

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium (Se) compounds have demonstrated antioxidant and antidepressant-like effects; however, most reported molecules are highly lipophilic. In contrast, moderate water solubility is considered crucial for drug delivery and therapeutic application. Accordingly, Se-containing pyridinium salts emerge as promising candidates for depression treatment. In this study, we conducted a comprehensive evaluation of three Se-based pyridinium salts (designated as compounds

Indexed as

Antidepressive AgentsPyridinium CompoundsSeleniumAnimalsAntioxidantsBrainComputer SimulationDepressionDose-Response Relationship, DrugHindlimb SuspensionLipid PeroxidationMaleMiceMonoamine OxidaseMonoamine Oxidase InhibitorsAntidepressive AgentsAntioxidantsMonoamine OxidaseMonoamine Oxidase InhibitorsPyridinium CompoundsSeleniumantidepressantantioxidantmicemonoamine oxidase inhibitorpyridinium saltsseleniumtoxicity

Identifiers

PMID40939165
PMCPMC12498411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.