The impact of Asic2 deletion on metabolic homeostasis in mice.
Madison Hamby, Jasleen Kaur, Seth Lirette, Jussara M do Carmo, Joshua Speed, Tawhida Islam, Emily Hildebrandt, Elizabeth Barr, Lavanya Challagundala, Heather A Drummond
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Madison HambyDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jasleen KaurDepartment of Cell and Molecular Biology and Genomics Core Facility, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Seth LiretteDepartment of Data Science, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jussara M do CarmoDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Joshua SpeedDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0002-0131-5253
Tawhida IslamDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Emily HildebrandtDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Elizabeth BarrDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Lavanya ChallagundalaDepartment of Cell and Molecular Biology and Genomics Core Facility, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Heather A DrummondDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0002-7171-804X
Funding
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4M
Sex differences in operant cocaine memoriesP20GM144041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ramona Moles · 2023 to 2026
$12.1M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Cardiac protective mechanisms of melanocortin system activationR01HL163076 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jussara M. Do Carmo, Alexandre Alves da Silva · 2023 to 2026
$2.3M
Endothelin-1 in Obesity and Insulin ResistanceR01DK124327 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI SPEED, JOSHUA S · 2021 to 2025
$2.2M
Degenerin and TrpC6 channels in renal vascular mechanosesnsor signaling and protection against injury.R01DK137167 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Heather A Drummond, Thomas R Kleyman · 2024 to 2026
$1.8M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5T32HL105324HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL163076HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK124327HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK137167HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM104357HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM144041NHLBI NIH HHS R01 HL163076NHLBI NIH HHS T32 HL105324NIDDK NIH HHS R01 DK124327NIDDK NIH HHS R01 DK137167NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM144041NIGMS NIH HHS P30 GM149404
6 · The paper itself
Abstract
Acid-Sensing Ion Channel 2 (Asic2) is expressed in many brain regions, including the hypothalamus, the homeostatic center for hunger-satiety-energy expenditure. We used the HypoMap reference atlas of the mouse hypothalamus to localize Asic2 message in the specific hypothalamic regions and found that Asic2 is the predominant degenerin subunit expressed in mouse hypothalamic neurons in the ventromedial, lateral, and arcuate regions and is expressed in pro-opiomelanocortin (Pomc), agouti-related peptide (Agrp), as well as leptin (Lepr) and insulin receptors (Insr) positive neurons. Thus, we investigated if Asic2 plays an important role in body weight control and energy expenditure before and after high-fat diet (HFD). Asic2
Indexed as
Acid Sensing Ion ChannelsEnergy MetabolismHomeostasisAnimalsDiet, High-FatFemaleGhrelinHypothalamusInsulinLeptinMaleMiceMice, Inbred C57BLMice, KnockoutAcid Sensing Ion ChannelsASIC2 protein, mouseGhrelinInsulinLeptindegenerindiet induced obesityenergy balance
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The impact of Asic2 deletion on metabolic homeostasis in mice. · full record | OpenQuestion