ArticleNeurology2025
Association of a History of Preterm Delivery With Stroke Risk in the Black Women's Health Study.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectivesBlack women experience a higher burden of preterm delivery and stroke compared with other American women. In a recent meta-analysis, history of preterm delivery was associated with an increased risk of stroke. However, previous studies were largely based on White women. This association has not been studied among Black women.
methodsWe conducted a prospective cohort study consisting of self-identified Black women across the United States. Participants were parous women, free of cardiovascular disease, and enrolled in the Black Women's Health Study (BWHS). Exposure was a self-reported history of preterm delivery. Outcome was all incident stroke cases, including self-reported stroke identified from questionnaires, stroke adjudicated through medical records, and fatal stroke identified using the National Death Index. Cox proportional hazard models were used, adjusting for maternal reproductive factors and risk factors of stroke.
resultsDuring a median of 20 years of follow-up among 41,788 parous Black women (mean age 40.5 years [SD 10.7]), 6,891 women reported a history of preterm delivery and 1,554 had incident stroke. Compared with women with no history of preterm delivery, Black women with a history of preterm delivery had a 1.30-fold increased stroke incidence (age-adjusted hazard ratio 1.30, 95% CI 1.14-1.47). The elevated stroke risk persisted after adjusting for history of hypertensive disorder during pregnancy and among the subset of stroke cases that were adjudicated through medical records reviewed by neurologists. DISCUSSION: In this prospective study of Black women, preterm delivery was associated with a 23% higher risk of long-term stroke. This study was limited by lack of detailed information on each pregnancy over the life course of Black women. Most of the BWHS participants were already parous at the time of enrollment in 1995. Information on the reasons for preterm delivery, timing and number of preterm deliveries, and prepregnancy risk factors is lacking. Our validation study on stroke was conducted among a small and nonrandom sample of participants who provided medical records. The negative predictive value of self-reported stroke was not assessed. The higher rate of preterm delivery likely contributes to the higher burden of stroke among Black women.
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