Evidence map›Paper›PMID 40938992›Full record

ArticleScience advances2025

The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles.

Kim Vikhe Patil, Nil Campamà Sanz, Kylie Hin-Man Mak, Wei Yang, Karl Annusver, Jasson Makkar, David Grommisch, Li Lei, Priyanka Sharma, Ryan R Driskell and 2 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kim Vikhe PatilDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9676-9997
Nil Campamà SanzDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7811-5663
Kylie Hin-Man MakDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3823-9060
Wei YangDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7083-7872
Karl AnnusverDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-9515-7216
Jasson MakkarSchool of Molecular Biosciences, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-7643-170X
David GrommischDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2666-1419
Li LeiDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6977-9791
Priyanka SharmaInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.ORCID 0000-0003-3890-3590
Ryan R DriskellSchool of Molecular Biosciences, Washington State University, Pullman, Washington, USA.ORCID 0000-0001-7673-2564
Maria KasperDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Maria GenanderDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2428-8040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posttranslational protein modifications have emerged as a mechanism regulating progenitor cell state transitions during tissue formation. Herein, we exploit the stereotyped hair follicle development to delineate the function of PADI4, an enzyme converting peptidylarginine to citrulline. Single-cell sequencing places

Indexed as

Cell ProliferationHair FollicleProtein-Arginine Deiminase Type 4Protein BiosynthesisStem CellsAnimalsCell DifferentiationCitrullinationMicePhosphorylationProtein Processing, Post-Translationalpeptidylarginine deiminase 4, mouseProtein-Arginine Deiminase Type 4

Identifiers

PMID40938992
PMCPMC12429026

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.