Evidence map›Paper›PMID 40938914›Full record

ArticlePloS one2025

The increase in varus tilt of the joint line convergence angle under weight-bearing is correlated with medial meniscus extrusion in patients with knee osteoarthrosis.

Yosuke Ishii, Akinori Nekomoto, Goki Kamei, Atsuo Nakamae, Takato Hashizume, Kexin Zhu, Miharu Sugimoto, Kohei Matsumura, Makoto Takahashi, Nobuo Adachi

Erratum issuedAbstract read
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In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yosuke IshiiDepartment of Bio-Environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0003-4517-5202
Akinori NekomotoDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Goki KameiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Atsuo NakamaeDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Takato HashizumeDepartment of Biomechanics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kexin ZhuDepartment of Biomechanics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Miharu SugimotoDepartment of Biomechanics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kohei MatsumuraDepartment of Biomechanics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Makoto TakahashiDepartment of Biomechanics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Nobuo AdachiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased medial meniscus extrusion (MME) in weight-bearing conditions is a critical factor associated with knee osteoarthritis (OA) progression and is not an alternative indicator in nonweight-bearing. This feature is related to mechanical stress. However, its correlation with varus knee alignment, reflecting the loading stress on the medial compartment, is still unknown. This study aimed to determine whether increased MME is associated with varus limb alignment.

methodSeventy patients with knee OA were recruited for this cross-sectional study. The MME was assessed using ultrasonography. Knee alignments were determined by whole-leg radiography in the standing position, and factors related to the loading stress on the medial compartment of the knee joint were detected, such as the hip-knee-ankle angle, percentage of the mechanical axis, medial proximal tibial angle, and joint line convergence angle (JLCA). MME and JLCA were evaluated under two conditions: nonweight-bearing and weight-bearing, and the increased values were determined as the difference between the conditions (Δ values).

resultsMME and JLCA were significantly higher in the weight-bearing condition than in the nonweight-bearing. The described alignment for MME under nonweight-bearing in the liner model was HKAA, where the ΔMME was ΔJLCA.

conclusionThe factors of increased MME in weight-bearing conditions differed from those of MME in nonweight-bearing conditions, as shown by the amount of change in JLCA under loading stress.

Indexed as

Knee JointMenisci, TibialOsteoarthritis, KneeWeight-BearingAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedUltrasonography

Identifiers

PMID40938914
PMCPMC12431272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.