Evidence map›Paper›PMID 40938898›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

Airway sympathectomy attenuates inflammation, transcriptional ratios of Muc5ac and Muc5b, and airway mechanic deficits in mice delivered intranasal IL-13.

Pedro Trevizan-Baú, Amy L Fagan, Shanil P Amin, Leah R Reznikov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pedro Trevizan-BaúDepartment of Physiological Sciences, University of Florida, Gainesville, Florida, United States.ORCID 0000-0003-2915-3337
Amy L FaganDepartment of Physiological Sciences, University of Florida, Gainesville, Florida, United States.
Shanil P AminDepartment of Physiological Sciences, University of Florida, Gainesville, Florida, United States.
Leah R ReznikovDepartment of Physiological Sciences, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-4074-9070

Funding

Central Nervous System Plasticity in Airway DiseaseR01HL152101 · NHLBI · UNIVERSITY OF FLORIDA · PI REZNIKOV, LEAH R · 2021 to 2025
$1.9M
Cystic Fibrosis Foundation (CFF) REZNIK23Y3Evelyn F. McKnight Brain Research Foundation (MBRF) Gator NeuroScholarsHHS | National Institutes of Health (NIH) HL152101NHLBI NIH HHS R01 HL152101
6 · The paper itself

Abstract

Excessive mucus in the airways is an underlying pathological feature of many airway diseases, including asthma. Therapeutic options to reduce mucus production in the airways remain limited. One possible therapeutic target is the airway sympathetic nerves. Although lung sympathetic innervation has been considered sparse, sympathetic nerves secrete neurotransmitters that act on adrenergic receptors, including β

Indexed as

InflammationInterleukin-13LungMucin 5ACMucin-5BSympathectomyAdministration, IntranasalAnimalsMaleMiceMice, Inbred C57BLMucusOxidopamineTranscription, GeneticInterleukin-13Muc5ac protein, mouseMuc5b protein, mouseMucin 5ACMucin-5BOxidopamineairway physiologyairway sympathetic nervesallergic asthmaflexiVentMuc5ac

Identifiers

PMID40938898
PMCPMC12671574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.