ArticleCancer biomarkers : section A of Disease markers2025
Role of immune cell subsets in liver fibrosis through single-cell RNA sequencing and array.
Article in Cancer biomarkers : section A of Disease markers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Unveiling the Immunopharmacological Mechanisms of Biejiajian Pills (BJJP) Underlying the Treatment of Hepatic Fibrosis: Insights From Network Pharmacology and Experimental Validation.Food science & nutrition · 2026Article
- The macrophage opera: from metabolic prolog to oncogenic crescendo in metabolic dysfunction-associated steatotic liver disease.Frontiers in medicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundImmune-inflammatory responses and dysregulation play a key role in liver fibrosis (LF) and cirrhosis progression, but the phenotypic and functional dynamics of immune cell populations remain poorly characterized.MethodsLF-related data from the GEO database were analyzed using ssGSEA to quantify immune cell infiltration and Kaplan-Meier analysis to assess the prognostic value of specific immune cell populations. Single-cell RNA sequencing data were used to establish an immune cell atlas, identify cell types linked to poor prognosis, and validate characteristic genes. Additionally, the functional distinctions and cell-cell interactions were further investigated.ResultsLF patients showed increased infiltration of monocytes, T cells, and NK cells, associated with poor outcomes. Genes linked to poor prognosis were markedly expressed in mononuclear phagocytes, T cells, and innate lymphoid cells (ILCs), which were further classified into 24 distinct subpopulations. Pro-fibrotic scar-associated macrophages and pro-inflammatory ILCs increased, while anti-inflammatory Kupffer cells and protective ILCs decreased. CCR7-expressing T cells and depletion-related genes were elevated in peripheral blood mononuclear cells, with ILCs showing increased expression of S1PR4 and S1PR5. Furthermore, macrophages expressing CD9 and IGFBP7 were identified.ConclusionThis study highlights immune heterogeneity in LF, identifying key cell populations linked to disease progression, offering potential immunotherapy targets.
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