Evidence map›Paper›PMID 40938566›Full record

ArticleAnnals of surgical oncology2025

The Combination of Chest Wall Perforator Flaps and Surgeon-Performed Breast Ultrasound: An Effective Synergy to Expand the Boundaries of Breast-Conserving Surgery.

Massimo Ferrucci, Francesco Milardi, Daniele Passeri, Elena Miglioranza, Paola Del Bianco, Giacomo Montagna, Alberto Marchet

Abstract read
In one paragraph

Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Massimo FerrucciBreast Surgery Unit, Veneto Institute of Oncology IOV, IRCSS - Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy. massimoferrucci@gmail.com.
Francesco MilardiDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Daniele PasseriDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Elena MiglioranzaDepartment of Vascular Surgery, Vita-Salute University School of Medicine, San Raffaele Scientific Institute, Milan, Italy.
Paola Del BiancoClinical Research Unit, Veneto Institute of Oncology IOV, IRCCS-Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy.
Giacomo MontagnaBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alberto MarchetBreast Surgery Unit, Veneto Institute of Oncology IOV, IRCSS - Istituto di Ricovero e Cura a Carattere Scientifico, Padova, Italy.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundIntraoperative ultrasound-guided breast-conserving surgery (IOUS) combined with chest wall perforator flaps (CWPFs) is a promising approach to avoid mastectomy, especially for patients with high anticipated resection-to-breast volume ratios (ARR) who would otherwise be ineligible for breast conservation.

methodsThis study prospectively analyzed surgical, oncologic, and cosmetic outcomes for consecutive patients with stages 0 to III breast cancer who underwent IOUS with CWPF-based partial breast reconstruction at a single institution between 2022 and 2024.

resultsThe study enrolled 73 female patients. The median age was 57 years, and the median tumor size was 32 mm, with 43.8% of lesions being multifocal/multicentric. The median ARR was 30.2%. The flap types included lateral intercostal artery perforator (LiCAP, 53.4%), anterior intercostal artery perforator (AICAP, 8.2%), medial intercostal artery perforator (MICAP, 19.2%), lateral thoracic artery perforator (LTAP, 16.4%), and thoracodorsal artery perforator (TDAP, 2.7%). The median flap volume was 90 cm

conclusionsThe combination of IOUS and CWPFs yielded favorable surgical, cosmetic, and short-term oncologic outcome. This approach effectively and safely expands the indications for breast conservation, avoiding mastectomies, particularly for patients with small-to-medium breasts and an unfavorable ARR.

Indexed as

Breast NeoplasmsMammaplastyMastectomy, SegmentalPerforator FlapThoracic WallUltrasonography, MammaryAdultAgedFemaleFollow-Up StudiesHumansMiddle AgedPrognosisProspective StudiesSurgeonsBreast cancerBreast conserving surgeryChest-wall perforator flapsIntraoperative ultrasoundMastectomy ratesPartial breast reconstruction

Identifiers

PMID40938566
PMCPMC12494625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.